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Titolo:
Experimental approaches to understanding virulence in toxoplasmosis
Autore:
Sibley, LD; Mordue, D; Howe, DK;
Indirizzi:
Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 l Microbiol, St Louis, MO 63110 USA Univ Kentucky, Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky Lexington KY USA 40546 ept Vet Sci, Lexington, KY 40546 USA
Titolo Testata:
IMMUNOBIOLOGY
fascicolo: 2, volume: 201, anno: 1999,
pagine: 210 - 224
SICI:
0171-2985(199912)201:2<210:EATUVI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONDII INFECTION; PERORAL INFECTION; PARASITOPHOROUS VACUOLE; MAMMALIAN-CELLS; PLASMA-MEMBRANE; EARLY SURVIVAL; CONGENIC MICE; CYST NUMBER; T-CELLS; ENCEPHALITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Sibley, LD Washington Univ, Sch Med, Dept Mol Microbiol, 660 S Euclid Ave,St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave St Louis MO USA 63110 3110 USA
Citazione:
L.D. Sibley et al., "Experimental approaches to understanding virulence in toxoplasmosis", IMMUNOBIOL, 201(2), 1999, pp. 210-224

Abstract

Toxoplasma gondii Is a widespread protozoan parasite that causes severe disease only in immunocompromised individuals. Equipped with excellent animalmodels and relatively advanced systems for genetics, T. gondii provides anexcellent system for understanding pathogenesis. desistance to toxoplasmosis is governed by rapid innate and adaptive immunity that is characterized by a Th1 type profile of cytokines. Despite this effective response, acute infections can cause considerable damage and the parasite effectively establishes a long-term chronic infection that predisposes the host to reactivation and provides a means of eventual transmission. This complex interactionis brought about by the differentiation of the parasite from a rapidly replicating, lyric form (known as the tachyzoite) to a slow-growing form (known as the bradyzoite) that gives rise to chronic infection. The population structure of T. gondii Is remarkably clonal, consisting of just three predominant lineages that are geographically widespread and found in a variety ofhosts including humans. Acute virulence is strongly associated with the type I genotype which exhibits an enhanced replication rate in vitro and higher tissue burdens in vitro relative to non-virulent lineages. The pathologyassociated with acute infection appears to be due to excessive production of acute inflammatory mediators, suggesting that disease is partly due to over-response of the host immune system. A combination of refined animal models and newly developed genetic cools for establishing the relative contribution of genes to pathogenesis will enable a comprehensive analysis of the molecular basis of virulence in toxoplasmosis.

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Documento generato il 29/03/20 alle ore 08:36:07