Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of glial K+ channels in ontogeny and gliosis: A hypothesis based uponstudies on Muller cells
Autore:
Bringmann, A; Francke, M; Pannicke, T; Biedermann, B; Kodal, H; Faude, F; Reichelt, W; Reichenbach, A;
Indirizzi:
Univ Leipzig, Paul Flechsig Inst Brain Res, Dept Neurophysiol, D-04109 Leipzig, Germany Univ Leipzig Leipzig Germany D-04109 rophysiol, D-04109 Leipzig, Germany Univ Leipzig, Hosp Eye, D-04109 Leipzig, Germany Univ Leipzig Leipzig Germany D-04109 Hosp Eye, D-04109 Leipzig, Germany
Titolo Testata:
GLIA
fascicolo: 1, volume: 29, anno: 2000,
pagine: 35 - 44
SICI:
0894-1491(20000101)29:1<35:ROGKCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; SPONTANEOUS SYNCHRONOUS ACTIVITY; RECTIFYING POTASSIUM CURRENTS; ALPHA-AMINOADIPIC ACID; CENTRAL NERVOUS-SYSTEM; EXTRACELLULAR POTASSIUM; RAT RETINA; ENDOTHELIAL-CELLS; MAMMALIAN RETINA; RABBIT RETINA;
Keywords:
inwardly rectifying K+ current; Ca2+-activated K+ current; transient K+ current; retinal glial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Bringmann, A Univ Leipzig, Paul Flechsig Inst Brain Res, Dept Neurophysiol, Jahnallee 59, D-04109 Leipzig, Germany Univ Leipzig Jahnallee 59 LeipzigGermany D-04109 g, Germany
Citazione:
A. Bringmann et al., "Role of glial K+ channels in ontogeny and gliosis: A hypothesis based uponstudies on Muller cells", GLIA, 29(1), 2000, pp. 35-44

Abstract

The electrophysiological properties of Muller cells, the principal glial cells of the retina, are determined by several types of K+ conductances. Both the absolute and the relative activities of the individual types of K+ channels undergo important changes in the course of ontogenetic development and during gliosis. Although immature Muller cells express inwardly rectifying K+ (K-IR) currents at a very low density, the membrane of normal mature Muller cells is predominated by the K-IR conductance. The K-IR channels mediate spatial buffering K+ currents and maintain a stable hyperpolarized membrane potential necessary for various glial-neuronal interactions. During "conservative" (i.e., non-proliferative) reactive gliosis, the K-IR conductance of Muller cells is moderately reduced and the cell membrane is slightlydepolarized; however, when gliotic Muller cells become proliferative, their K-IR conductances are dramatically down-regulated; this is accompanied byan increased activity of Ca2+-activated K+ channels and by a conspicuous unstability of their membrane potential. The resultant variations of the membrane potential may increase the activity of depolarization-activated K+, Na+ and Ca2+ channels. It is concluded that in respect to their K+ current pattern, mature Muller cells pass through a process of dedifferentiation before proliferative activity is initiated. GLIA 29:35-44, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:49:47