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Titolo:
Characterization of germinal center dendritic cells in follicular lymphoma
Autore:
Renard, N; Valladeau, J; Barthelemy, C; Ribeiro, P; Berger, F; Saeland, S; Salles, G;
Indirizzi:
Ctr Hosp Lyon Sud, Hematol Serv, F-69495 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69495 495 Pierre Benite, France Hop Edouard Herriot, Hospices Civils Lyon, Serv Anat Pathol, Pierre Benite, France Hop Edouard Herriot Pierre Benite France Pathol, Pierre Benite, France Univ Lyon 1, UPRES JE Pathol Cellules Lymphoides, Pierre Benite, France Univ Lyon 1 Pierre Benite France ules Lymphoides, Pierre Benite, France Schering Plough, Lab Immunol Res, Dardilly, France Schering Plough Dardilly France ough, Lab Immunol Res, Dardilly, France
Titolo Testata:
EXPERIMENTAL HEMATOLOGY
fascicolo: 12, volume: 27, anno: 1999,
pagine: 1768 - 1775
SICI:
0301-472X(199912)27:12<1768:COGCDC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; B-CELL; LYMPHOCYTES; EXPRESSION; SUBSETS; B7-1;
Keywords:
germinal center dendritic cells; follicular lymphomas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Salles, G Ctr Hosp Lyon Sud, Hematol Serv, F-69495 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69495 Benite, France
Citazione:
N. Renard et al., "Characterization of germinal center dendritic cells in follicular lymphoma", EXP HEMATOL, 27(12), 1999, pp. 1768-1775

Abstract

A subset of dendritic cells called germinal center dendritic cells (GCDC) has recently been described inside germinal center from reactive lymphoid organs. We investigated this newly recognized population in follicular lymphoma (FL), which is considered to be the pathologic counterpart of germinal center B cells. Immunohistochemistry analysis with a panel of antibodies demonstrated the presence of a cell population with the peculiar GCDC phenotype in FL biopsies and a similar localization of these cells inside tumoral and reactive follicles. Therefore, we analyzed the relationships between GCDC and the other cell subsets of the tumor follicles. Some of CD4(+) and CD8(+) T lymphocytes present inside the follicle were found to be in close association with GCDC, suggesting a potential implication of GCDC in their activation. In addition, the distribution of GCDC inside FL and reactive follicles did not appear disrupted, in contrast to follicular dendritic cells, the other follicle dendritic cell type. Finally, we demonstrated that GCDC could be detected from FL lymph node cell suspension by flow cytometry. Taken together, these results indicate that FL development is not associated with a disappearance of GCDC or with a lack of physical interactions betweenGCDC and T cells inside the follicles. In addition, the fact that GCDC canbe observed in FL samples by now cytometry should allow their purificationto further study their putative role in FL development and maintenance. (C) 1999 International Society for Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:55:33