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Titolo:
Effects of testosterone suppression in young men by the gonadotropin releasing hormone antagonist cetrorelix on plasma lipids, lipolytic enzymes, lipid transfer proteins, insulin, and leptin
Autore:
Buchter, D; Behre, HM; Kliesch, S; Chirazi, A; Nieschlag, E; Assmann, G; von Eckardstein, A;
Indirizzi:
Univ Munster, Zent Lab, Inst Klin Chem & Lab Med, D-48129 Munster, GermanyUniv Munster Munster Germany D-48129 & Lab Med, D-48129 Munster, Germany Univ Munster, Fak Med, Interdisziplinares Zentrum Klin Forsch, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 in Forsch, D-48129 Munster, Germany Univ Munster, Inst Reprod Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 eprod Med, D-48129 Munster, Germany Univ Munster, Klin & Poliklin Geburtshilfe & Frauenheilkunde, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 heilkunde, D-48129 Munster, Germany Univ Munster, Inst Arterioskleroseforsch, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 oseforsch, D-48129 Munster, Germany
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 8, volume: 107, anno: 1999,
pagine: 522 - 529
SICI:
0947-7349(1999)107:8<522:EOTSIY>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; PHOSPHOLIPID TRANSFER PROTEIN; ESTER TRANSFER PROTEIN; HDL-CHOLESTEROL; ENDOGENOUS TESTOSTERONE; POSTHEPARIN PLASMA; HEPATIC LIPASE; SERUM LEVELS; A-I;
Keywords:
androgens; HDL; insulin resistance; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: von Eckardstein, A Univ Munster, Zent Lab, Inst Klin Chem & Lab Med, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
D. Buchter et al., "Effects of testosterone suppression in young men by the gonadotropin releasing hormone antagonist cetrorelix on plasma lipids, lipolytic enzymes, lipid transfer proteins, insulin, and leptin", EXP CL E D, 107(8), 1999, pp. 522-529

Abstract

We investigated in a pilot study the effect of testosterone suppression onlipoprotein metabolism, insulin, and leptin in 10 men who were treated either with cetrorelix, an antagonist of gonadotropin releasing hormone, or with placebo (P). Group C + C (n = 4) was treated with 10 mg cetrorelix as daily subcutaneous injections for five days and with a subsequent injection of 60 mg cetrorelix depot. Group C + P (n = 3) received 10 mg cetrorelix as daily intramuscular injections for five days and a subsequent injection of placebo depot. Group P + P (n = 3) received placebo both as daily and depotinjections. Treatment with cetrorelix reversibly suppressed testosterone to castrate levels for three weeks in group C + C and for one week in group C + P. Compared to baseline, treatment with cetrorelix increased serum levels of apolipoprotein (apo) A-I, HDL subclass LpA-I, insulin, and leptin. Inthe group P + P,treatment with placebo was not associated with any change of these parameters. Compared to baseline and group P + P, treatment with cetrorelix ill groups C + C and C + P did not lead to considerable or consistent changes in the plasma activities of lecithin:cholesterol acyltransferase (LCAT), phospholipid transfer protein (PLTP), cholesteryl ester transferprotein (CETP), lipoprotein lipase, and hepatic lipase (HL). Only the pooled data of groups C + C and C + P unraveled small but statistically significant decreases of HL and CETP activities in response to cetrorelix. In conclusion, the small or absent effects of cetrorelix on LCAT, CETP, PLTP, LPL,and HL indicate that testosterone regulates HDL levels by other metabolic pathways. The increases of insulin and leptin in response to cetrorelix suggest that testosterone influences HDL metabolism also via obesity and insulin resistance. These effects, however, are rather in contrast to the HDL raising effect of suppressed testosterone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:52:20