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Titolo:
Flow limitation and dyspnoea in healthy supine subjects during methacholine challenge
Autore:
Sulc, J; Volta, CA; Ploysongsang, Y; Eltayara, L; Olivenstein, R; Milic-Emili, J;
Indirizzi:
McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada McGill Univ Montreal PQ Canada H2X 2P2 Labs, Montreal, PQ H2X 2P2, Canada McGill Univ, Montreal Chest Inst, Res Ctr, Montreal, PQ H2X 2P2, Canada McGill Univ Montreal PQ Canada H2X 2P2 Ctr, Montreal, PQ H2X 2P2, Canada
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 6, volume: 14, anno: 1999,
pagine: 1326 - 1331
SICI:
0903-1936(199912)14:6<1326:FLADIH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; MAXIMAL EXPIRATORY FLOW; INDUCED BRONCHOCONSTRICTION; ASTHMATIC SUBJECTS; LUNG-INFLATION; HYPERINFLATION; REACTIVITY; RESISTANCE; TONE;
Keywords:
dynamic hyperinflation; forced expiratory volume in one second; inspiratory capacity; negative expiratory pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Milic-Emili, J McGill Univ, Meakins Christie Labs, 3626 St Urbain St, Montreal, PQ H2X 2P2, Canada McGill Univ 3626 St Urbain St Montreal PQ Canada H2X 2P2 da
Citazione:
J. Sulc et al., "Flow limitation and dyspnoea in healthy supine subjects during methacholine challenge", EUR RESP J, 14(6), 1999, pp. 1326-1331

Abstract

The purpose of this study was to assess whether during standard methacholine (Mch) challenge (concentration up to 128 mg.mL(-1)) healthy supine subjects a) develop tidal expiratory flow limitation (FL) and hyperinflation, and b) whether the onset of tidal PL is associated with dyspnoea. Eight healthy subjects were studied. Dyspnoea was assessed using the Borg scale, FL by the negative expiratory pressure (NEP) method and hyperinflation in terms of decrease in inspiratory capacity (IC). Seven patients became flow limited at Mch doses ranging 4-64 mg.mL(-1), with PL encompassing 34-84% of the control tidal volume. In six of them the onset of tidal FL was associated,vith little or no dyspnoea and a modest degree of hyperinflation (Delta IC <-0.4 L). In one subject, however, onset ofFL was associated with a substantial reduction in IC (0.58 L) and moderately severe dyspnoea. In all of these seven subjects PL was transiently reversed after an IC manoeuvre. In conclusion, the results show that a) most healthy subjects may develop now limitation and hyperinflation during methacholine challenge in supine position, and b) at onset of flow limitation there is lime or no dyspnoea, suggesting that onset of dynamic airway compression per se does not elicit significant dyspnoea. Significant dyspnoea probably only occurs with marked dynamic hyperinflation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:29:47