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Titolo:
Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats
Autore:
Amano, K; Takamatsu, J; Ogata, A; Katsuragi, S; Miyazaki, C; Deshimaru, M; Sumiyoshi, S; Miyakawa, T;
Indirizzi:
Kikuchi Natl Hosp, Dept Psychiat, Kumamoto 8611116, Japan Kikuchi Natl Hosp Kumamoto Japan 8611116 ychiat, Kumamoto 8611116, Japan Kikuchi Natl Hosp, Dept Clin Res, Kumamoto 8611116, Japan Kikuchi Natl Hosp Kumamoto Japan 8611116 in Res, Kumamoto 8611116, Japan Kumamoto Univ, Fac Educ, Kumamoto 8600862, Japan Kumamoto Univ Kumamoto Japan 8600862 , Fac Educ, Kumamoto 8600862, Japan Kumamoto Univ, Sch Med, Dept Neuropsychiat, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 ropsychiat, Kumamoto 8600811, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 385, anno: 1999,
pagine: 111 - 117
SICI:
0014-2999(199912)385:2-3<111:EODCOA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAZEPAM; TOLERANCE; DIPHENYLHYDANTOIN; DOGS;
Keywords:
dipotassium clorazepate; anticonvulsive; amygdaloid; hippocampal; kindling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Amano, K Kikuchi Natl Hosp, Dept Psychiat, Kumamoto 8611116, Japan KikuchiNatl Hosp Kumamoto Japan 8611116 umamoto 8611116, Japan
Citazione:
K. Amano et al., "Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats", EUR J PHARM, 385(2-3), 1999, pp. 111-117

Abstract

We examined the effect of dipotassium clorazepate (7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-4-benzodiazepine-3-carboxylate potassium hydroxide), an antianxiety drug, on amygdaloid kindling and compared its effects for 7 successive days on amygdaloid- versus hippocampal-kindled seizures, using the ratkindling model of epilepsy. Dipotassium clorazepate at 5 mg/kg significantly delayed amygdaloid kindling. The contralateral cortical after-discharge duration in the dipotassium clorazepate-treated group was significantly shorter than the after-discharge duration in the amygdala in the first seven stimulations, whereas it was significantly shorter only in the first three stimulations in the control group, indicating that dipotassium clorazepate suppressed the spread of seizure activity from focus to contralateral cortex. Dipotassium clorazepate suppressed amygdaloid-kindled seizures at 2 and 5mg/kg, while 1 mg/kg or more suppressed hippocampal-kindled seizures. Thus, differences in effective dosages in both amygdaloid- and hippocampal-kindled seizures may suggest a difference in the neuronal mechanisms involved in this kindling. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:53:26