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Titolo:
Mechanisms underlying the relaxation caused by the sesquiterpene polygodial in vessels from rabbit and guinea-pig
Autore:
Andre, E; Malheiros, A; Cechinel, V; Yunes, RA; Calixto, JB;
Indirizzi:
Univ Fed Santa Catarina, Dept Pharmacol, CCB, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Florianopolis SC Brazil BR-88015420 BC SC, Brazil Univ Fed Santa Catarina, Dept Chem, CCB, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Florianopolis SC Brazil BR-88015420 BC SC, Brazil
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 386, anno: 1999,
pagine: 47 - 53
SICI:
0014-2999(199912)386:1<47:MUTRCB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; TRACHEA IN-VITRO; NITRIC-OXIDE; POTASSIUM CHANNELS; DRYMIS-WINTERI; GUANYLYL CYCLASE; K+ CHANNELS; CYCLIC-GMP; INHIBITION; EXTRACT;
Keywords:
polygodial; relaxation; aorta, rabbit; pulmonary artery, rabbit; pulmonary artery, guinea-pig; nitric oxide (NO);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Calixto, JB Univ Fed Santa Catarina, Dept Pharmacol, CCB, Rua Ferreira Lima 82, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Rua Ferreira Lima 82 Florianopolis SC Brazil BR-88015420 BC
Citazione:
E. Andre et al., "Mechanisms underlying the relaxation caused by the sesquiterpene polygodial in vessels from rabbit and guinea-pig", EUR J PHARM, 386(1), 1999, pp. 47-53

Abstract

The sesquiterpene polygodial produces graded relaxation in rings of rabbitpulmonary artery or thoracic aorta and guinea-pig pulmonary artery with endothelium. In rings with rubbed endothelium its vasorelaxant action was largely reduced. The N-omega-nitro-L-arginine (L-NOARG), N-G-nitro-L-arginine methyl ester (L-NAME), 6-anilino-5,8-quinolinedione (LY 83583) and 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), inhibited the endothelium-dependent vasorelaxant action of polygodial. In contrast, N-omega-nitro-D-arginine (D-NOARG). indomethncin, N-2-[(4R)-4-hydroxy-1-(1methyl-1H-indol-3yl)carbonyl-L-prolyl]-N-methyl-N-phenylmenthyl-3-(2-naphthyl)-L-alaninamide (FK 888), (S)-N-methyl-N[4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl]benzamide (SR 48968), (8R, 9S, 11S)-(-)-9-hydroxy-9-n-hexyloxy-carbonyl-8-methyl-2,3,9,20-tetrahydro-8,11-epoxy-1H,8H,11N-2,7b,11a-triaqzadibenzo [a, g]cycloocta[c, d, e]-trinden-1-one (KT 5720), calcitocin gene-related peptide receptor antagonist (CGRP-(8-37), apamin, charybdotoxin and 4-aminopyridine had no effect on polygodial action. However, glibenclamide inhibited partially, but significantly, its relaxant responses. These results demonstrate that the vasorelaxation of polygodial is partly dependent on the release of nitric oxide (NO)or an NO-derived substance from the vascular endothelium through an activation of a guanylyl cyclase-dependent mechanism. Finally, results demonstrate that the polygodial vasorelaxant action is not related with the opening of potassium (K+) channels, release of prostacyclin, substance P, or with the activation of adenylyl cyclase-dependent mechanisms. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:35:49