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Titolo:
Absolute quantitation of iodine-123 epidepride kinetics using single-photon emission tomography: comparison with carbon-11 epidepride and positron emission tomography
Autore:
Almeida, P; Ribeiro, MJ; Bottlaender, M; Loch, C; Langer, O; Strul, D; Hugonnard, P; Grangeat, P; Maziere, B; Bendriem, B;
Indirizzi:
Hosp Garcia de Orta, Nucl Med Serv, P-2801 Almada, Portugal Hosp Garcia deOrta Almada Portugal P-2801 Serv, P-2801 Almada, Portugal CEA, Serv Hosp Frederic Joliot, DSV, DRM, F-91406 Orsay, France CEA Orsay France F-91406 rederic Joliot, DSV, DRM, F-91406 Orsay, France Fac Med Coimbra, IBILI, Serv Biofis, Coimbra, Portugal Fac Med Coimbra Coimbra Portugal IBILI, Serv Biofis, Coimbra, Portugal CEA, Lab Elect Technol & Instrumentat, DTA, DSYS, Grenoble, France CEA Grenoble France Technol & Instrumentat, DTA, DSYS, Grenoble, France
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 12, volume: 26, anno: 1999,
pagine: 1580 - 1588
SICI:
0340-6997(199912)26:12<1580:AQOIEK>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENUATION CORRECTION; DOPAMINE TRANSPORTERS; SPECT QUANTIFICATION; PARKINSONS-DISEASE; I-123 EPIDEPRIDE; LINE SOURCE; HUMAN BRAIN; PET; COMPENSATION; RECEPTORS;
Keywords:
absolute quantitation; single-photon emission tomography; positron emission tomography; dopamine receptors; imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Almeida, P Hosp Garcia de Orta, Nucl Med Serv, Bairro Matadouro Pragal, P-2801 Almada, Portugal Hosp Garcia de Orta Bairro Matadouro Pragal Almada Portugal P-2801
Citazione:
P. Almeida et al., "Absolute quantitation of iodine-123 epidepride kinetics using single-photon emission tomography: comparison with carbon-11 epidepride and positron emission tomography", EUR J NUCL, 26(12), 1999, pp. 1580-1588

Abstract

Epidepride labelled with iodine-123 is a suitable probe for the in vivo imaging of striatal and extrastriatal dopamine D-2 receptors using single-photon emission tomography (SPET), Recently, this molecule has also been labelled with carbon-11. The goal of this work was to develop a method allowing the in vivo quantification of radioactivity uptake in baboon brain using SPET and to validate it using positron emission tomography (PET). SPET studies were performed in Papio anubis baboons using I-123-epidepride. Emission and transmission measurements were acquired on a dual-headed system with variable head angulation and low-energy ultra-high resolution (LEUHR) collimation. The imaging protocol consisted of one transmission measurement (24 min, heads at 90 degrees), obtained with two sliding line sources of gadolinium-153 prior to injection of 0.21-0.46 GBq of I-123-epidepride, and 12 emission measurements starting 5 min post injection. For scatter correction (SC)we used a dual-window method adapted to I-123. Collimator blurring correction (CBC) was done by deconvolution in Fourier space and attenuation correction (AT) was applied on a preliminary (CBC) filtered back-projection reconstruction using 12 iterations of a preconditioned, regularized minimal residual algorithm. For each reconstruction, a calibration factor was derived from a uniform cylinder filled with a I-123 solution of a known radioactivity concentration. Calibration and baboon images were systematically built with the same reconstruction parameters. Uncorrected (UNC) and (AT), (SC+AT) and (SC+CBC+AT) corrected images were compared. PET acquisitions using 0.11-0.44 GBq of C-11-epidepride were performed on the same baboons and used asa reference. The radioactive concentrations expressed in percent of the injected dose per 100 mi (%ID/100 ml) obtained after (SC+CBC+AT) in SPET are in good agreement with those obtained with PET and C-11-epidepride. A method for the in vivo absolute quantitation of I-123-epidepride uptake using SPET has been developed which can be directly applied to other I-123-labelledmolecules used in the study of the dopamine system. Further work will consist in using PET to model the radioligand-receptor interactions and to derive a simplified model applicable in SPET.

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Documento generato il 27/01/20 alle ore 16:50:52