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Titolo:
Management of airway manifestations of relapsing polychondritis - Case reports and review of literature
Autore:
Sarodia, BD; Dasgupta, A; Mehta, AC;
Indirizzi:
Cleveland Clin Fdn, Dept Pulm & Crit Care Med, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 re Med, Cleveland, OH 44195 USA Kelsey Seybold Clin, Dept Pulm & Crit Care Med, Houston, TX USA Kelsey Seybold Clin Houston TX USA Pulm & Crit Care Med, Houston, TX USA
Titolo Testata:
CHEST
fascicolo: 6, volume: 116, anno: 1999,
pagine: 1669 - 1675
SICI:
0012-3692(199912)116:6<1669:MOAMOR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-FUNCTION; COMPLICATIONS; STENTS;
Keywords:
bronchial obstruction; bronchial stenosis; endoscopic treatment; relapsing polychondritis; metal stents; self-expandable stents; tracheal obstruction; tracheal stenosis; tracheobronchomalacia; Wallstent;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Mehta, AC Cleveland Clin Fdn, Dept Pulm & Crit Care Med, 9500 Euclid Ave,Desk A-90, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave,Desk A-90 Cleveland OH USA 44195
Citazione:
B.D. Sarodia et al., "Management of airway manifestations of relapsing polychondritis - Case reports and review of literature", CHEST, 116(6), 1999, pp. 1669-1675

Abstract

Study objective: To report the first series of patients with severe airwaymanifestations of relapsing polychondritis (RP) that were managed successfully with self-expandable metallic stents, and to review the literature. Design: Retrospective review of medical records, and current clinical follow-up. Setting: Tertiary care referral hospital. Patients: All patients with airway manifestations of RP that were managed with self-expandable metallic stents at our institution. Results: All five patients (four women and one man; age, 40 to 69 years old) had severe airway manifestations, and three of them required mechanical ventilation. Spirometry. with flow-volume curves showed severe combined obstructive and restrictive ventilatory defects. Bronchoscopy revealed dynamiccollapse of the proximal airways. Diagnosis was made 8 months to 13 years after the first symptom of the disease, Pharmacotherapy included prednisone, methotrexate, cyclosporine, and dapsone, A total of 17 self-expandable metallic stents of varying sizes were placed using flexible bronchoscope from4 to 19 years after the first symptom. The overall outcome was favorable in four patients, Three patients have survived without ventilatory support 16 to 18 months following the first stent placement, and the fourth patient survived for 20 months without ventilatory support before she died, The fifth patient, who was receiving mechanical ventilation, died in 1 week probably due to persistent dynamic collapse of the airways distal to the stents,Conclusion: Self-expandable metallic tracheobronchial stents should be considered in the management of airway manifestations of RP, especially in patients who require mechanical ventilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:41:45