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Titolo:
Antibiotic resistance in microbes
Autore:
Mazel, D; Davies, J;
Indirizzi:
Inst Pasteur, Dept Biotechnol, UPMTG, F-75724 Paris 15, France Inst Pasteur Paris France 15 Biotechnol, UPMTG, F-75724 Paris 15, France Univ British Columbia, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada TerraGen Discovery, Vancouver, BC V6T 1Z3, Canada TerraGen Discovery Vancouver BC Canada V6T 1Z3 couver, BC V6T 1Z3, Canada
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 9-10, volume: 56, anno: 1999,
pagine: 742 - 754
SICI:
1420-682X(19991130)56:9-10<742:ARIM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEISSERIA-MENINGITIDIS; SULFONAMIDE RESISTANCE; STREPTOCOCCUS-PNEUMONIAE; PENICILLIN RESISTANCE; SALMONELLA-TYPHIMURIUM; DIHYDROPTEROATE SYNTHASE; PATHOGENICITY ISLANDS; GENETIC DIVERSITY; ESCHERICHIA-COLI; DRUG-RESISTANCE;
Keywords:
horizontal gene transfer; integron; acquisition; mutation; ecology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, J Inst Pasteur, Dept Biotechnol, UPMTG, 25-28 Rue Dr Roux, F-75724Paris 15,France Inst Pasteur 25-28 Rue Dr Roux Paris France 15 Paris 15,France
Citazione:
D. Mazel e J. Davies, "Antibiotic resistance in microbes", CELL MOL L, 56(9-10), 1999, pp. 742-754

Abstract

The treatment of infectious disease is compromised by the development of antibiotic-resistant strains of microbial pathogens. A variety of biochemical processes are involved that may keep antibiotics out of the cell, alter the target of the drug, or disable the antibiotic. Studies have shown that resistance determinants arise by either of two genetic mechanisms: mutation and acquisition. Antibiotic resistance genes can be disseminated among bacterial populations by several processes,but principally by conjugation. Thusthe overall problem of antibiotic resistance is one of genetic ecology anda better understanding of the contributing parameters is necessary to devise rational approaches to reduce the development and spread of antibiotic resistance and so avoid a critical situation in therapy-a return to a pre-antibiotic era.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:38:34