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Titolo:
Decreased serotonin transporter binding in unaffected relatives of manic depressive patients
Autore:
Leboyer, M; Quintin, P; Manivet, P; Varoquaux, O; Allilaire, JF; Launay, JM;
Indirizzi:
Hop Albert Chenevier & Henri Mondor, Psychiat Serv, AP, HP, F-94000 Creteil, France Hop Albert Chenevier & Henri Mondor Creteil France F-94000 eteil, France Hop La Pitie Salpetriere, CNRS, UMR 7593, AP,HP, Paris, France Hop La Pitie Salpetriere Paris France S, UMR 7593, AP,HP, Paris, France Hop La Pitie Salpetriere, Psychiat Serv, AP, HP, Paris, France Hop La Pitie Salpetriere Paris France chiat Serv, AP, HP, Paris, France Hop Lariboisiere, Serv Biochim, AP, HP, F-75475 Paris, France Hop Lariboisiere Paris France F-75475 him, AP, HP, F-75475 Paris, France Hop Mignot, Serv Biochim, Versailles, France Hop Mignot Versailles France p Mignot, Serv Biochim, Versailles, France
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 12, volume: 46, anno: 1999,
pagine: 1703 - 1706
SICI:
0006-3223(199912)46:12<1703:DSTBIU>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; GENE POLYMORPHISMS; IMIPRAMINE BINDING; PLATELET; ASSOCIATION; UNIPOLAR; PLASMA;
Keywords:
manic depressive illness; endophenotype; serotonin; serotonin transporter gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Leboyer, M Hop Albert Chenevier & Henri Mondor, Psychiat Serv, AP, HP, 40 Rue Mesly, F-94000 Creteil, France Hop Albert Chenevier & Henri Mondor 40 Rue Mesly Creteil France F-94000
Citazione:
M. Leboyer et al., "Decreased serotonin transporter binding in unaffected relatives of manic depressive patients", BIOL PSYCHI, 46(12), 1999, pp. 1703-1706

Abstract

Background: There are numerous reports of decreased binding to platelet serotonin transporter (5-HTT) in depression, suggesting that it might be considered a trait marker of depression. To further investigate whether reduced5-HTT function could be an endophenotype in manic depressive illness, we looked for abnormalities of platelet 5-HTT among subjects who are potential carriers of genetic vulnerability to manic depressive illness (MDI). Methods: Blood samples were obtained from 20 unaffected relatives from families with at least two individuals with bipolar disorder and from 19 control participants. Plasma 5-HIAA, platelet 5-HT, and [H-3] imipramine bindingwere measuredResults: Unaffected relatives manifested lower platelet 5-HTT function than control participants as revealed both by reduced number and diminished affinity of imipramine binding sites and diminished platelet 5-HT content. Conclusions: These preliminary results suggest that reduced 5-HTT functioncould be considered a trait marker or an endophenotype in MDI. Biol Psychiatry 1999;46: 1703-1706 (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:56:29