Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinical and biochemical characteristics of type 2 diabetic patients on continuous ambulatory peritoneal dialysis: Relationships with insulin requirement
Autore:
Wong, TYH; Chan, JCN; Szeto, CC; Leung, CB; Li, PKT;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong Chinese Univ Hong Kong Shatin Hong Kong & Therapeut, Shatin, Hong Kong
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 3, volume: 34, anno: 1999,
pagine: 514 - 520
SICI:
0272-6386(199909)34:3<514:CABCOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; CONVERTING ENZYME-ACTIVITY; CROSS-SECTIONAL ASSESSMENT; PLASMA C-PEPTIDE; CREATININE CLEARANCES; METABOLIC CONTROL; WEEKLY UREA; MELLITUS; RESISTANCE; THERAPY;
Keywords:
type 2 diabetes mellitus; end-stage renal failure (ESRF); continuous ambulatory peritoneal dialysis (CAPD); insulin resistance; homeostasis model analysis (HOMA); pancreatic beta-cell function; insulin requirement; serum angiotensin-converting enzyme (ACE) activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Li, PKT Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong Chinese Univ Hong Kong Shatin Hong Kong peut, Shatin, Hong Kong
Citazione:
T.Y.H. Wong et al., "Clinical and biochemical characteristics of type 2 diabetic patients on continuous ambulatory peritoneal dialysis: Relationships with insulin requirement", AM J KIDNEY, 34(3), 1999, pp. 514-520

Abstract

Although glycemic control has an important impact on the clinical outcomesof patients with diabetes undergoing dialysis, there is a paucity of data on the relationship between glucose metabolism and clinical parameters in these patients. In this study, we compared a cohort of 48 patients with typeII diabetes undergoing continuous ambulatory peritoneal dialysis (CAPD) with 84 age- and sex-matched patients with type II diabetes with similar disease duration but normal renal function. Compared with those with normal renal function, patients with type 2 diabetes undergoing CAPD had greater serum angiotensin-converting enzyme activity (median, 57.4 U/L; range, 33.5 to 100.0 U/L v 46.9 U/L; range, 11.6 to 111.2 U/L; P < 0.005), fasting C-peptide (median, 9.1 ng/mL; range, 0.9 to 30.0 ng/mL v 2.2 ng/mL; range, 0.2 to 20.3 ng/mL; P < 0.0001) and triglyceride levels, and lower serum albumin concentrations. Among the patients undergoing CAPD, there was a preponderanceof men in the insulin-treated group. Insulin-treated patients also had greater plasma albumin levels and body weights and lower fasting serum C-peptide levels (2.81 +/- 1.77 v 3.12 +/- 2.04 ng/mL; analysis of variance, P = 0.007 adjusted for fasting glucose concentration). Multivariate analysis showed duration of diabetes, hemoglobin A(1c) (HbA(1c)) level, and body weightwere independent determinants of insulin requirement in patients undergoing CAPD. The daily Insulin dosage required was related to the duration of diabetes (r = 0.5; P = 0.007). In summary, among patients with end-stage renal failure, insulin-treated patients had greater body weights and plasma albumin levels but lower cholesterol levels. Plasma C-peptide concentration and duration of diabetes were the main determinants of Insulin requirement, reflecting a decrease In beta-cell reserve, whereas the daily insulin dose correlated mainly with body weight, HbA(1c) level, and duration of diabetes. KW had no effect on insulin resistance or insulin requirement of the patients. (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:39:45