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Titolo:
Dynamics of impending overt hypothyroidism: spontaneous evolution in patients before treatment
Autore:
Huber, G; Guglielmetti, M; Huber, P; Kunz, M; Roth, CB; Staub, JJ;
Indirizzi:
Univ Kliniken Basel, Kantonsspital, Abt Endokrinol, Dept Innere Med, Basel, Switzerland Univ Kliniken Basel Basel Switzerland pt Innere Med, Basel, Switzerland Univ Kliniken Basel, Kantonsspital, Med Klin B, Dept Innere Med, Basel, Switzerland Univ Kliniken Basel Basel Switzerland pt Innere Med, Basel, Switzerland
Titolo Testata:
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT
fascicolo: 48, volume: 129, anno: 1999,
pagine: 1893 - 1895
SICI:
0036-7672(199912)129:48<1893:DOIOHS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
GER
Soggetto:
SUBCLINICAL HYPOTHYROIDISM; DOUBLE-BLIND; WOMEN;
Keywords:
subclinical hypothyreoidism; TSH; fT4; thyroid reserve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Huber, G Univ Basel, Med Klin B, Dept Innere Med, Petersgraben 4, CH-4031 Basel, Switzerland Univ Basel Petersgraben 4 Basel Switzerland CH-4031 Switzerland
Citazione:
G. Huber et al., "Dynamics of impending overt hypothyroidism: spontaneous evolution in patients before treatment", SCHW MED WO, 129(48), 1999, pp. 1893-1895

Abstract

The syndrome of subclinical hypothyroidism, with its clinical and metabolic consequences, is frequent. Only a minority of these patients will eventually become overtly hypothyroid. It was the aim of the present study to analyse the spontaneous evolution over 10 years of 27 patients with subclinicalhypothyroidism who became overtly hypothyroid (group A). For comparison, 27 patients remaining subclinically hypothyroid and matched for their TSH concentrations were characterised (group B). In group A, continuous increase of TSH concentrations was observed over the whole observation period (p = 0.002; ANOVA). The concentrations of fT4 remained initially stable, and onlyfell at a late stage in the three years before overt hypothyroidism (p = 0.0001; ANOVA). The concentrations of total T3 remained normal throughout the observation period. Thyroid reserve was already impaired at the beginningand during the whole study period. In contrast, these thyroid parameters of patients of group B remained unchanged over 10 years, and thyroid reserveremained normal. The pathogenesis of overt hypothyroidism is a graded process. Increasing concentrations of TSH, a decrease of fT4 and impaired thyroid reserve are predictors of overt thyroid failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:15:51