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Titolo: Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus
Autore: Criswell, KA; Loch-Caruso, R;
- Indirizzi:
- Univ Michigan, Sch Publ Hlth M6112 2, Dept Environm Hlth Sci, Toxicol Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 col Program, Ann Arbor, MI 48109 USA
- Titolo Testata:
- REPRODUCTIVE TOXICOLOGY
fascicolo: 6,
volume: 13,
anno: 1999,
pagine: 481 - 490
- SICI:
- 0890-6238(199911/12)13:6<481:LIOSCO>2.0.ZU;2-Y
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- GAP JUNCTIONAL COMMUNICATION; HEXACHLOROCYCLOHEXANE ISOMERS; POLYCHLORINATED-BIPHENYLS; ORGANOCHLORINE COMPOUNDS; REPRODUCTIVE FUNCTION; ESTROGENIC ACTION; SMOOTH-MUSCLE; MECHANISM; PREMATURE; CELLS;
- Keywords:
- lindane; inhibition of uterine contraction; hexachlol-ocyclohexane; cyclic AMP; uterus; pregnant rat; pregnant uterus; quinacrine; antagonism of lindane action in uterus; myometrium;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 54
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Loch-Caruso, R Univ Michigan, Sch Publ Hlth M6112 2, Dept Environm Hlth Sci, Toxicol Program, 1420 Washington Hts, Ann Arbor, MI 48109 USA Univ Michigan 1420 Washington Hts Ann Arbor MI USA 48109 SA
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- Citazione:
- K.A. Criswell e R. Loch-Caruso, "Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus", REPROD TOX, 13(6), 1999, pp. 481-490
Abstract
Hexachlorocyclohexanes (HCHs) are prevalent insecticides. Lindane (gamma-HCH) inhibits uterine gap junctions but beta-HCH does not. Because gap junctions promote coordination of oscillatory uterine contractions, we hypothesized that lindane, but not beta-HCH, would inhibit uterine contractions. Uterine strips from midgestation rats were suspended in standard muscle baths and exposed to HCHs in a cumulative manner. Lindane induced concentration-dependent decreases in contraction force (ED50 of 9.2 mu M) and complete uterine quiescence at 30 mu M. In contrast, beta-HCH had no effect on contraction force, but 20 to 200 mu M beta-HCH increased contraction frequency in aconcentration-dependent manner. Isomer-specific differences in uterine responses were observed at similar HCH isomer tissue concentrations. Additionally, the phospholipase A(2) inhibitor and antioxidant quinacrine increased the ED50 for contraction force inhibition to 84.5 mu M lindane. Lindane also increased cAMP concentrations. Lindane and beta-HCH have distinctly different actions in the uterus. Lindane's inhibitory action may involve cAMP, arachidonic acid, or oxidative stress. (C) 1999 Elsevier Science Inc. All rights reserved.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 07:44:55