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Titolo:
Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders
Autore:
Verhoeff, NPLG;
Indirizzi:
Univ Toronto, Ctr Addict & Mental Hlth, PET Ctr, Schizophrenia Div, Toronto, ON M5T 1R8, Canada Univ Toronto Toronto ON Canada M5T 1R8 a Div, Toronto, ON M5T 1R8, Canada
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 147, anno: 1999,
pagine: 217 - 249
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; I-123 BETA-CIT; D-2 RECEPTOR OCCUPANCY; MULTIPLE-SYSTEM ATROPHY; PROGRESSIVE SUPRANUCLEAR PALSY; AGE-RELATED-CHANGES; NAIVE SCHIZOPHRENIC-PATIENTS; DOPA-RESPONSIVE DYSTONIA; INHERITED OLIVOPONTOCEREBELLAR ATROPHY; EARLY PARKINSONS-DISEASE;
Keywords:
dopamine; receptor; transporter; SPECT; PET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
370
Recensione:
Indirizzi per estratti:
Indirizzo: Verhoeff, NPLG Univ Toronto, Ctr Addict & Mental Hlth, PET Ctr, Schizophrenia Div, ClarkeSite,Room 745,250 Coll St, Toronto, ON M5T 1R8, Canada Univ Toronto Clarke Site,Room 745,250 Coll St Toronto ON Canada M5T 1R8
Citazione:
N.P.L.G. Verhoeff, "Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders", PSYCHOPHAR, 147(3), 1999, pp. 217-249

Abstract

This article will review the capabilities and accomplishments of radiotracer imaging with single photon emission computed tomography (SPECT) and positron emission tomography (PET) to measure pre-, post-, and "intra-synaptic"aspects of dopaminergic (DAergic) neurotransmission. The presynaptic site can be labeled with probes for the dopamine transporter (DAT) or the synthetic enzyme aromatic L-amino acid decarboxylase ("dopa decarboxylase"). The postsynaptic sites can be labeled with probes for either the dopamine D-1 receptor (D1R) or the dopamine D-2 receptor (D2R). The "synaptic" measurements are made indirectly by measurements of the interaction/displacement of receptor tracers by endogenous dopamine (DA). Agents are used which either release (e.g., amphetamine) or deplete (e.g., alpha-methyl-paratyrosine (AMPT), an inhibitor of tyrosine hydroxylase) tissue stores of DA. The application of these paradigms will be reviewed with special emphasis to neuropsychiatric diseases such as schizophrenia and idiopathic Parkinson's disease (IPD).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:28:18