Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs
Autore:
Borowicz, KK; Kleinrok, Z; Czuczwar, SJ;
Indirizzi:
Lublin Med Univ Sch, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland Lublin Med Univ Sch Lublin Poland PL-20090 icol, PL-20090 Lublin, Poland Inst Agr Med, Dept Clin Toxicol, PL-20950 Lublin, Poland Inst Agr Med Lublin Poland PL-20950 lin Toxicol, PL-20950 Lublin, Poland
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 6, volume: 40, anno: 1999,
pagine: 509 - 516
SICI:
1043-6618(199912)40:6<509:IO3ASR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROSHOCK-INDUCED SEIZURES; INDUCED NEURONAL ACTIVATION; CA(3) DORSAL HIPPOCAMPUS; PROTECTIVE EFFICACY; BEHAVIORAL EVIDENCE; MEMORY PROCESSES; NMDA ANTAGONIST; INDUCED AMNESIA; MODULATING ROLE; NEUROPEPTIDE-Y;
Keywords:
3-PPP; sigma ligand; sigma receptor; antiepileptic drugs; electroshock maximal; seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Czuczwar, SJ Lublin Med Univ Sch, Dept Pharmacol & Toxicol, Jaczewskiego 8, PL-20090 Lublin, Poland Lublin Med Univ Sch Jaczewskiego 8 Lublin PolandPL-20090 nd
Citazione:
K.K. Borowicz et al., "Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs", PHARMAC RES, 40(6), 1999, pp. 509-516

Abstract

(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg(-1), 30 min before the test, significantlydecreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg(-1)) diminished the protective activity of diphenylhydantoin, phenobarbital and valproate, but not that of carbamazepine against maximal electroshock. The effect of 3-PPP upon the electroconvulsive threshold and the 3-PPP-induced inhibition of the protective action of antiepileptics was reversed by haloperidol (0.5 mg kg(-1)). Moreover, 3-PPP didnot alter the total and free plasma levels of antiepileptic drugs, so a pharmacokinetic interaction is not probable. The combined treatment of 3-PPP with antiepileptic drugs, providing a 50% protection against maximal electroshock, did not affect motor performance in mice, although resulted in significant long-term memory deficits. Our data indicate that sigma receptor-mediated events may play some role in seizure processes in the central nervous system and can modulate the protective activity of some conventional antiepileptic drugs. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:41:38