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Titolo:
Thyrotropin releasing hormone stimulation of GABA-gated but not basal chloride ion influx in rat cerebellum
Autore:
Imamura, M; Yamada, M; Mori, M; Prasad, C;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Med, Endocrinol Sect, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Gunma Univ, Sch Med, Dept Internal Med 1, Gunma 3718511, Japan Gunma UnivGunma Japan 3718511 Dept Internal Med 1, Gunma 3718511, Japan
Titolo Testata:
PEPTIDES
fascicolo: 11, volume: 20, anno: 1999,
pagine: 1375 - 1379
SICI:
0196-9781(199911)20:11<1375:TRHSOG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABAERGIC SYNAPTIC TRANSMISSION; HIPPOCAMPAL SLICE; TRH; NEURONS; ANALOGS; INVOLVEMENT; TA-0910; SYSTEM;
Keywords:
TRH; DN 1417; TA 0910; chloride channel; gamma-amino-butyric acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Prasad, C Louisiana State Univ, Med Ctr, Dept Med, Endocrinol Sect, 1542 Tulane Ave,New Orleans, LA 70112 USA Louisiana State Univ 1542 Tulane Ave New Orleans LA USA 70112 SA
Citazione:
M. Imamura et al., "Thyrotropin releasing hormone stimulation of GABA-gated but not basal chloride ion influx in rat cerebellum", PEPTIDES, 20(11), 1999, pp. 1375-1379

Abstract

Potential interaction between gamma-amino butyric acid (GABA) and thyrotropin-releasing hormone (TRH) in eliciting a variety of central nervous system (CNS)-related biologic activities is well known; however, the mechanism underlying this interaction is not clearly defined. To gain further insight into this interaction, we examined the effects of TRH and two of its central nervous system selective analogs, DN 1417 and TA 0910, on basal and GABA-mediated chloride ion influx into rat cerebellar neurosynaptosomes. The results of these studies show that TRH may facilitate GABA action by augmenting chloride ion influx and hyperpolarization of cerebellar neurons. (C) 1999Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:13:53