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Titolo:
Infection of mice by a Toxoplasma gondii isolate from an AIDS patient: virulence and activation of hosts' immune responses are independent of parasite genotype
Autore:
Haque, S; Hanna, S; Gharbi, S; Franck, J; Dumon, H; Haque, A;
Indirizzi:
Dartmouth Coll, Sch Med, Dept Med & Microbiol, Hanover, NH 03755 USA Dartmouth Coll Hanover NH USA 03755 ed & Microbiol, Hanover, NH 03755 USA Univ Mediterranee, Fac Med, INSERM, U399, F-13385 Marseille, France Univ Mediterranee Marseille France F-13385 99, F-13385 Marseille, France
Titolo Testata:
PARASITE IMMUNOLOGY
fascicolo: 12, volume: 21, anno: 1999,
pagine: 649 - 657
SICI:
0141-9838(1999)21:12<649:IOMBAT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; T-CELL; LYMPHOCYTES-T; IFN-GAMMA; INTRACELLULAR PATHOGEN; PROTECTIVE IMMUNITY; INTERFERON-GAMMA; CONGENIC MICE; NITRIC-OXIDE; TNF-ALPHA;
Keywords:
Toxoplasma gondii; virulence; IFN-gamma; TNF-alpha; NK cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Haque, A Dartmouth Coll, Sch Med, Dept Med & Microbiol, Hanover, NH 03755 USA Dartmouth Coll Hanover NH USA 03755 obiol, Hanover, NH 03755 USA
Citazione:
S. Haque et al., "Infection of mice by a Toxoplasma gondii isolate from an AIDS patient: virulence and activation of hosts' immune responses are independent of parasite genotype", PARASITE IM, 21(12), 1999, pp. 649-657

Abstract

Virulence of a Toxoplasma gondii isolate from an AIDS patient (designated as PTN) was compared with that of PLK, a variant of P-strain. Virulence wasassessed in term of host survival upon inoculation in different strains ofmice. All C57BL/6 mice died of acute toxoplasmosis by 7-10 days following intraperitoneal infection with 1 x 10(5) tachyzoites of PTN and 40% of BALB/c died on day 23 of infection, whereas 100% CBA/J infected with the same dose of PTN survived, as did outbred Swiss Webster mice. All C57BL/6, BALB/c, CBA/J, or Swiss Webster died of acute toxoplasmosis by 3-9 days postinfection upon inoculation with same dose of tachyzoites of the PLK strain. Further studies in CBA/J mice demonstrated that mice infected with PTN eliciteda significantly higher lymphoproliferative response to crosslinked anti-CD3 mAb or Con A than PLK infected mice, and augmented production of TNF alpha, lower levels of nitrite and a higher number of NK cells. Genetical analysis indicated that both PLK and PTN strains of T. gondii are from type ll. Interestingly, being of the same genotype, the later showed less virulence upon inoculation in mice and had greater capacity to activate host immune system than the PLK strain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:15:38