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Titolo:
Potentiating effects of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide (PEPA) on excitatory synaptic transmission in dentate granule cells
Autore:
Nakagawa, T; Iino, M; Sekiguchi, M; Wada, K; Ozawa, S;
Indirizzi:
Gunma Univ, Sch Med, Dept Physiol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Degenerat Neurol Dis,Kodaira, Tokyo 187, Japan Natl Ctr Neurol & Psychiat Kodaira Tokyo Japan 187 aira, Tokyo 187, Japan
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 35, anno: 1999,
pagine: 217 - 223
SICI:
0168-0102(199912)35:3<217:PEO4>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-RECEPTOR DESENSITIZATION; RAT HIPPOCAMPAL SLICES; SULFONAMIDE DERIVATIVES; POSTSYNAPTIC CURRENTS; OPERATED CHANNELS; TIME COURSE; ANIRACETAM; NEURONS; AMPA; CYCLOTHIAZIDE;
Keywords:
AMPA receptor; nootropic drug; PEPA; desensitization; excitatory postsynaptic current; dentate granule cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ozawa, S Gunma Univ, Sch Med, Dept Physiol, 3-39-22 Showa Machi, Maebashi,Gumma 3718511, Japan Gunma Univ 3-39-22 Showa Machi Maebashi Gumma Japan 3718511 Japan
Citazione:
T. Nakagawa et al., "Potentiating effects of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide (PEPA) on excitatory synaptic transmission in dentate granule cells", NEUROSCI RE, 35(3), 1999, pp. 217-223

Abstract

A novel sulfonylamino compound, 4-[2-(phenylsulfonylamino)-ethylthio]-2,6-difluro-phenoxyacetamide (PEPA) has been shown to selectively potentiate glutamate-induced currents in Xenopus oocytes expressing recombinant AMPA receptor subunits, GluR1-GluR4, by attenuation of desensitization. Here, we examined the effects of PEPA on responses to excitatory amino acids as well as on excitatory synaptic transmission in dentate granule cells of rat hippocampal slices using the whole-cell patch clamp technique. PEPA at 100 mu M produced a 3-4-fold increases in the peak amplitude of current responses toAMPA and glutamate applied iontophoretically in the dentate granule cells,whereas it showed no effect on NMDA-induced currents. Excitatory postsynaptic currents (EPSCs) evoked in these neurons by stimulation of the perforant path had fast and slow components mediated by AMPA and NMDA receptors, respectively. PEPA at concentrations between 10 and 100 mu M potentiated onlythe AMPA component of the EPSC (AMPA EPSC) in a dose-dependent manner without affecting the NMDA component. Although the potentiating effect of PEPA on the amplitude of the AMPA EPSC was weaker than that on the AMPA-induced current, it clearly prolonged the duration of the EPSC. PEPA at 100 mu M increased the peak ampitude of the AMPA EPSC by 17%, and increased the area enclosed by the AMPA EPSC by 72%. (C) 1999 Elsevier Science Ireland Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 04:58:41