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Titolo:
Uncoupling of cerebral blood flow and glucose utilization in the regenerating facial nucleus after axotomy
Autore:
Ito, D; Tanaka, K; Nagata, E; Suzuki, S; Dembo, T; Fukuuchi, Y;
Indirizzi:
Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Neurol, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 35, anno: 1999,
pagine: 207 - 215
SICI:
0168-0102(199912)35:3<207:UOCBFA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROTROPHIC FACTOR PREVENTS; FIBRILLARY ACIDIC PROTEIN; MOTOR-NEURONS; HYPOGLOSSAL NUCLEUS; NERVE-SECTION; BRAIN; RAT; DEATH; MOTONEURONS; ASTROCYTES;
Keywords:
axotomy; cerebral blood flow; glucose metabolism; regeneration; degeneration; facial nerve; astroglia; microglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, D Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 Tokyo 1608582, Japan
Citazione:
D. Ito et al., "Uncoupling of cerebral blood flow and glucose utilization in the regenerating facial nucleus after axotomy", NEUROSCI RE, 35(3), 1999, pp. 207-215

Abstract

Axotomy is known to activate various metabolic processes including proteinsynthesis and glucose utilization in the motor nucleus. Although it is generally assumed that the local cerebral blood flow (CBF) fluctuates in response to the axonal reaction, there has been no direct evidence for changes in CBF in the motor nucleus following axotomy. In this study, the CBF in thefacial nuclei was measured after axotomy of the facial nerve employing the[(14) C]iodoantipyrine method to evaluate the relation between the CBF andaxonal reaction. Following unilateral facial nerve axotomy in neonates, which induced neuronal degeneration in the facial nucleus, the CBF and glucose uptake was significantly decreased on the operated nucleus, suggesting that CBF and glucose metabolism are coupled in the degenerating nucleus. In contrast, after axotomy in adults, which induced regeneration of neurons andglial reactions, glucose uptake was increased on the operated nucleus, while the CBF did not differ significantly between the operated and unoperatednucleus. These findings imply that glucose metabolism and CBF are uncoupled in the regenerating nucleus, suggesting that the relation between CBF andmetabolism in the regenerating nucleus following axotomy may clearly contradict the classical concept of a tight coupling between CBF and metabolism. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:06:01