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Titolo:
Reduction of intracerebral hemorrhaging in a rabbit embolic stroke model
Autore:
Hu, BR; Liu, CL; Zivin, JA;
Indirizzi:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA San Diego Vet Affairs Med Ctr, San Diego, CA USA San Diego Vet Affairs MedCtr San Diego CA USA ed Ctr, San Diego, CA USA
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 53, anno: 1999,
pagine: 2140 - 2145
SICI:
0028-3878(199912)53:9<2140:ROIHIA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE HYPERTENSION; CEREBRAL EMBOLISM; TRANSFORMATION; ISCHEMIA; INFARCT; EDEMA; RAT;
Keywords:
cerebral hemorrhage; cerebrovascular disorders; free radicals; cell death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Zivin, JA Univ Calif San Diego, Dept Neurosci, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 93 USA
Citazione:
B.R. Hu et al., "Reduction of intracerebral hemorrhaging in a rabbit embolic stroke model", NEUROLOGY, 53(9), 1999, pp. 2140-2145

Abstract

Objective: To study the effects of a spin trap agent and a CD18 antibody administered after stroke induction on intracerebral hemorrhaging. The drugscan prevent leukocyte adhesion. Methods: A rabbit embolic stroke model that produces intracerebral hemorrhage was used. Results: A time course study showed that hemorrhaging was grossly apparent in approximately 50% of the subjects at 5 hours and in 75% at 24 hours after embolization. MDL 101,002, a spin trap agent, administered IV 5 minutes after embolization, significantly decreased the volume of hemorrhage. It also improved the behavior scorerelative to vehicle-treated rabbits. The CD18 antibody tended to decrease hemorrhage volume. Conclusion: The beneficial effect of MDL 101,002 may be caused by inhibition of free radical injury to brain tissue, thereby protecting brain microvessel integrity. Acute therapy for intracerebral hemorrhage may be feasible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:45:12