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Titolo:
Gender differences in the incidence of AD and vascular dementia - The EURODEM Studies
Autore:
Andersen, K; Launer, LJ; Dewey, ME; Letenneur, L; Ott, A; Copeland, JRM; Dartigues, JF; Kragh-Sorensen, P; Baldereschi, M; Brayne, C; Lobo, A; Martinez-Lage, JM; Stijnen, T; Hofman, A;
Indirizzi:
Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, EURODEM, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Odense Univ, Dept Psychiat, DK-5230 Odense M, Denmark Odense Univ OdenseDenmark M v, Dept Psychiat, DK-5230 Odense M, Denmark Royal Liverpool Hosp, Dept Psychiat, Liverpool, Merseyside, England Royal Liverpool Hosp Liverpool Merseyside England l, Merseyside, England INSERM U330, Bordeaux, France INSERM U330 Bordeaux FranceINSERM U330, Bordeaux, France Natl Res Council, Targetet Program Ageing, Florence, Italy Natl Res Council Florence Italy argetet Program Ageing, Florence, Italy Univ Cambridge, Inst Publ Hlth, Cambridge CB2 1TN, England Univ CambridgeCambridge England CB2 1TN lth, Cambridge CB2 1TN, England Univ Zaragoza, Dept Psychiat, E-50009 Zaragoza, Spain Univ Zaragoza Zaragoza Spain E-50009 t Psychiat, E-50009 Zaragoza, Spain Univ Navarra, Dept Neurol, E-31080 Pamplona, Spain Univ Navarra PamplonaSpain E-31080 Dept Neurol, E-31080 Pamplona, Spain
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 53, anno: 1999,
pagine: 1992 - 1997
SICI:
0028-3878(199912)53:9<1992:GDITIO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROBABLE ALZHEIMERS-DISEASE; MENTAL-STATE; PREVALENCE; POPULATION; ESTROGEN; RISK; AGE; DIAGNOSIS; WOMEN; PREDICTORS;
Keywords:
epidemiology; incidence study; dementia; AD; vascular dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Andersen, K Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, EURODEM, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR rlands
Citazione:
K. Andersen et al., "Gender differences in the incidence of AD and vascular dementia - The EURODEM Studies", NEUROLOGY, 53(9), 1999, pp. 1992-1997

Abstract

Objective: To study the difference in risk for dementing diseases between men and women. Background: Previous studies suggest women have a higher risk for dementia than men. However, these studies include small sample sizes,particularly in the older age groups, when the incidence of dementia is highest. Methods: Pealed analysis of four population-based prospective cohortstudies was performed. The sample included persons 65 years and alder, 528incident cases of dementia, and 28,768 person-years of follow-up. Incidentcases were identified in a two-stage procedure in which the total cohort was screened for cognitive impairment, and screen positives underwent detailed diagnostic assessment. Dementia and main subtypes of AD and vascular dementia were diagnosed according to internationally accepted guidelines. Sex-and age-specific incidence rates, and relative and cumulative risks for total dementia, AD, and vascular dementia were calculated using log linear analysis and Poisson regression. Results: There were significant gender differences in the incidence of AD after age 85 years. At 90 years of age, the rate was 81.7 (95% CI, 63.8 to 104.7) in women and 24.0 (95% CI, 10.3 to 55.6) in men. There were no gender differences in rates or risk for vascular dementia. The cumulative risk for 65-year-old women to develop AD at the ageof 95 years was 0.22 compared with 0.09 for men. The cumulative risk for developing vascular dementia at the age of 95 years was similar for men and women (0.04). Conclusion: Compared with men, women have an increased risk for AD. There are no gender differences in risk for vascular dementia.

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Documento generato il 18/09/20 alle ore 16:45:19