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Titolo:
Marital status and risk of Alzheimer's disease - A French population-basedcohort study
Autore:
Helmer, C; Damon, D; Letenneur, L; Fabrigoule, C; Barberger-Gateau, P; Lafont, S; Fuhrer, R; Antonucci, T; Commenges, D; Orgogozo, JM; Dartigues, JF;
Indirizzi:
Univ Bordeaux 2, INSERM U330, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 M U330, F-33076 Bordeaux, France CHU, Federat Neurol, Bordeaux, France CHU Bordeaux FranceCHU, Federat Neurol, Bordeaux, France INSERM U360, Paris, France INSERM U360 Paris FranceINSERM U360, Paris, France Univ Michigan, Inst Social Res, Ann Arbor, MI USA Univ Michigan Ann ArborMI USA higan, Inst Social Res, Ann Arbor, MI USA
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 53, anno: 1999,
pagine: 1953 - 1958
SICI:
0028-3878(199912)53:9<1953:MSAROA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEMENTIA; MORTALITY; EPIDEMIOLOGY; COMMUNITY; PAQUID; AGE; MEN;
Keywords:
dementia; AD; risk factor; marital status;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Helmer, C Univ Bordeaux 2, INSERM U330, 146 Rue Leo Siagnat, F-33076 Bordeaux, France Univ Bordeaux 2 146 Rue Leo Siagnat Bordeaux France F-33076 nce
Citazione:
C. Helmer et al., "Marital status and risk of Alzheimer's disease - A French population-basedcohort study", NEUROLOGY, 53(9), 1999, pp. 1953-1958

Abstract

Objective: To analyze the relationship between marital status and risk of AD or dementia. Methods: This study was carried out from the Personnes Agees QUID (PAQUID) cohort, an epidemiologic study on normal and pathologic aging after age 65 years. The PAQUID cohort began in 1988. Individuals were followed up at 1, 3, and 5 years, with an active detection of dementia. Marital status was divided into four categories: widowed, never married, divorced or separated, and the reference category, married or cohabitant. The longitudinal relationship between marital status and risk of incident AD or dementia was analyzed by a Cox model with delayed entry. Results: Among the 3,675 individuals initially not demented, 2,106 were married or cohabitants, 1,287 were widowers, 179 were never married, and 103 were divorced or separated. Among the 2,881 individuals reevaluated at least once for the risk ofdementia during the 5-year follow-up, 190 incident cases of dementia were identified, including 140 with AD. The relative risks (RRs) of dementia (RR= 1.91, p = 0.018) and of AD (RR = 2.68, p < 0.001) were increased for thenever-married individuals compared with those who were married or cohabitants. This excess of risk was specifically associated with AD. Adjustment for other risk factors of dementia (education, wine consumption), or for factors reflecting social environment, leisure activities, and depression, did not modify the risk of AD for never-married individuals (RR = 2.31,p = 0.02). Conclusions: We confirmed an association between marital status and AD, with an excess risk observed among never-married individuals. This association may provide clues about the pathogenesis of AD.

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Documento generato il 09/07/20 alle ore 14:24:33