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Titolo:
Multiple sclerosis is associated with enhanced B cell responses to the ganglioside GDIa
Autore:
Mata, S; Lolli, F; Soderstrom, M; Pinto, F; Link, H;
Indirizzi:
Univ Florence, Dipartimento Sci Neurol & Psichiatr, Serv Neurofisiopatol, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 fisiopatol, I-50134 Florence, Italy Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, S-14186 Huddinge, SwedenHuddinge Univ Hosp Huddinge Sweden S-14186 rol, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Ophthalmol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 mol, S-14186 Huddinge, Sweden
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 6, volume: 5, anno: 1999,
pagine: 379 - 388
SICI:
1352-4585(199912)5:6<379:MSIAWE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; GUILLAIN-BARRE-SYNDROME; CEREBROSPINAL-FLUID; NEUROLOGICAL DISORDERS; IMMUNE-COMPLEXES; OPTIC NEURITIS; ANTIBODIES; IGG; AUTOANTIBODIES;
Keywords:
multiple sclerosis; optic neuritis; ganglioside; autoantibodies; cardiolipin; sulfatide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Lolli, F Univ Florence, Dipartimento Sci Neurol & Psichiatr, Serv Neurofisiopatol, Viale Morgagni 85, I-50134 Florence, Italy Univ Florence Viale Morgagni 85 Florence Italy I-50134 ce, Italy
Citazione:
S. Mata et al., "Multiple sclerosis is associated with enhanced B cell responses to the ganglioside GDIa", MULT SCLER, 5(6), 1999, pp. 379-388

Abstract

The occurrence and role of autoantibodies to gangliosides and other lipid-containing components of the central nervous system in Multiple Sclerosis (MS) ore unsettled. Using sensitive ELISAs, we measured IgG and IgM antibodytiters and absorbances to the three major gangliosides GDIa GDIb and GMI, and to sulfatides, cardiolipin and myelin proteins in paired serum and cerebrospinol fluid (CSF) from patients with untreated MS optic neuritis (ON), acute aseptic meningo-encephalitis (AM) and other neurological diseases (OND). Twenty-three per cent of 30 MS (P<0.04) and 18% of 32 ON Patients (P<0.05) presented elevated IgG antibody titers to GDIa in serum compared to 9% of patients with OND. Six (40%) of the patients with malignant MS had elevated serum IgG antibody titers to GDIa compared to one (6%) of the patients with benign MS (P<0.04). In CSF, elevated IgG antibody titers to GD I a were measured in 13% of MS and 20% of ON patients compared to 4% of patients with OND (P<0.03 and P<0.02, respectively). The augmented IgG response to GDIa in serum also separated MS from Guillain-Barre syndrome. Compared to ONDincreased IgM absorbances to sulfatides and cardiolipin were observed in CSF of patients with MS, but also in AM. Elevated IgG antibody titers to myelin proteins were found more often in MS patients' serum and MS, ON and AM Patients' CSF compared to OND. The data implicate that among the multitude of enhanced B-cell responses occurring in MS and ON, that directed to GDIa is common and more discriminative, and should be evaluated in future MS treatment studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:18:36