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Titolo:
Tritiated kappa receptor antagonist norbinaltorphimine: Synthesis and in vitro binding in three different tissues
Autore:
Marki, A; Otvos, F; Toth, G; Hosztafi, S; Borsodi, A;
Indirizzi:
Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary Hungarian Acad Sci Szeged Hungary H-6701 Biochem, H-6701 Szeged, Hungary Hungarian Acad Sci, Biol Res Ctr, Isotope Lab, H-6701 Szeged, Hungary Hungarian Acad Sci Szeged Hungary H-6701 ope Lab, H-6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ, Dept Pharmacodynam, H-6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ Szeged Hungary H-6701 6701 Szeged, Hungary Alkaloida Chem Co Ltd, Tiszavasvari, Hungary Alkaloida Chem Co Ltd Tiszavasvari Hungary o Ltd, Tiszavasvari, Hungary
Titolo Testata:
LIFE SCIENCES
fascicolo: 1, volume: 66, anno: 1999,
pagine: 43 - 49
SICI:
0024-3205(19991126)66:1<43:TKRANS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE OPIOID ANTAGONIST; RAT-BRAIN MEMBRANES; NOR-BINALTORPHIMINE; LIGAND-BINDING; MU; NALTRINDOLE; DESIGN; POTENT; SITES; PEPTIDE;
Keywords:
kappa-opioid receptors; norbinaltorphimine; tritium labelling; binding studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Borsodi, A Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, POB 521, H-6701Szeged, Hungary Hungarian Acad Sci POB 521 Szeged Hungary H-6701 eged, Hungary
Citazione:
A. Marki et al., "Tritiated kappa receptor antagonist norbinaltorphimine: Synthesis and in vitro binding in three different tissues", LIFE SCI, 66(1), 1999, pp. 43-49

Abstract

Recently a new antagonist with high selectivity for the kappa receptors (norbinaltorphimine) was developed and tested in various systems. This compound was radiolabelled with tritium resulting in high specific radioactivity (47.2 Ci/mmol). [H-3]Norbinaltorphimine was characterized by in vitro radioligand binding assays. The radioligand binds to kappa-opioid receptors witha high potency and selectivity in guinea pig, frog and rat brain membranes. Our results suggest the kappa(1) specificity of the radioligand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:51:45