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Titolo:
Smooth muscle cell proliferation in the ductus arteriosus and the descending aorta, and effects of enalapril on SMC proliferation in perinatal rats
Autore:
Takizawa, T; Kawahata, M; Ikeda, Y; Yamamoto, M; Arishima, K; Muto, M; Masaoka, T;
Indirizzi:
Azabu Univ, Sch Vet Med, Dept Dev & Reprod Biotechnol, Sagamihara, Kanagawa 2298501, Japan Azabu Univ Sagamihara Kanagawa Japan 2298501 ara, Kanagawa 2298501, Japan Azabu Univ, Sch Vet Med, Dept Anat 2, Sagamihara, Kanagawa 2298501, Japan Azabu Univ Sagamihara Kanagawa Japan 2298501 ara, Kanagawa 2298501, Japan Azabu Univ, Sch Vet Med, Dept Surg 2, Sagamihara, Kanagawa 2298501, Japan Azabu Univ Sagamihara Kanagawa Japan 2298501 ara, Kanagawa 2298501, Japan Azabu Univ, Sch Vet Med, Dept Comparat Toxicol, Sagamihara, Kanagawa 2298501, Japan Azabu Univ Sagamihara Kanagawa Japan 2298501 ara, Kanagawa 2298501, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 11, volume: 61, anno: 1999,
pagine: 1215 - 1218
SICI:
0916-7250(199911)61:11<1215:SMCPIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA POLYMERASE-DELTA; AUXILIARY PROTEIN; NUCLEAR ANTIGEN; FETAL RATS; INDOMETHACIN; CLOSURE; ATHEROSCLEROSIS; RESPONSIVENESS; CONSTRICTION; INHIBITORS;
Keywords:
ductus arteriosus; enalapril; PCNA; proliferation; SMC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Takizawa, T Azabu Univ, Sch Vet Med, Dept Dev & Reprod Biotechnol, Sagamihara, Kanagawa 2298501, Japan Azabu Univ Sagamihara Kanagawa Japan 2298501 a 2298501, Japan
Citazione:
T. Takizawa et al., "Smooth muscle cell proliferation in the ductus arteriosus and the descending aorta, and effects of enalapril on SMC proliferation in perinatal rats", J VET MED S, 61(11), 1999, pp. 1215-1218

Abstract

This study was carried out to determine the proliferation profile of the smooth muscle cells (SMC) in the media of the ductus arteriosus (DA) and thedescending aorta (Ao), and to examine the effects of the angiotensin-converting enzyme inhibitor enalapril on the proliferation of these cells in perinatal rats. The proliferating cell nuclear antigen (PCNA) index of the DA peaked in 19-day-old fetuses at 75%, and the index significantly declined in 20-day-old fetuses. The PCNA index of the Ao showed a similar profile until pups reached 1 day of age; however, the index of the Ao then increased in 3-day-old pups. The PCNA indices of the DA and Ao decreased significantlyafter maternal oral treatment with enalapril (10 mg/kg for 7 days), with amore marked decline in the DA than in the Ao. The PCNA indices of these vessels in 20-day-old fetuses were not altered by maternal treatment with enalapril. These results indicate that the SMC proliferation rate in the DA was similar to that in the Ao until pups reached the age of 1 day, and that the inhibitory effect of enalapril on the SMC proliferation was age-dependent and more prominent in the DA than in the Ao.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:07:26