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Titolo:
Molecular pathogenesis of lung cancer
Autore:
Fong, KM; Sekido, Y; Minna, JD;
Indirizzi:
Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Therapeut Oncol Res, Dallas, TX 75235 USA Prince Charles Hosp, Brisbane, Qld 4032, Australia Prince Charles Hosp Brisbane Qld Australia 4032 bane, Qld 4032, Australia Nagoya Univ Hosp, Dept Clin Prevent Serv, Nagoya, Aichi, Japan Nagoya UnivHosp Nagoya Aichi Japan n Prevent Serv, Nagoya, Aichi, Japan
Titolo Testata:
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
fascicolo: 6, volume: 118, anno: 1999,
pagine: 1136 - 1152
SICI:
0022-5223(199912)118:6<1136:MPOLC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-SMALL-CELL; ENDOTHELIAL GROWTH-FACTOR; K-RAS ONCOGENE; RETINOBLASTOMA PROTEIN EXPRESSION; LYMPH-NODE METASTASIS; WILD-TYPE P53; SERUM ANTI-P53 ANTIBODIES; HER-2/NEU GENE-EXPRESSION; BOMBESIN-LIKE PEPTIDES; TUMOR-SUPPRESSOR GENE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
207
Recensione:
Indirizzi per estratti:
Indirizzo: Minna, JD Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 X 75235 USA
Citazione:
K.M. Fong et al., "Molecular pathogenesis of lung cancer", J THOR SURG, 118(6), 1999, pp. 1136-1152

Abstract

Lung cancer is the largest cancer killer of men and women in the United States. In addition to the progress made from antismoking primary prevention measures, new tools to help treat patients with lung cancer are emerging from the rapid advances in knowledge of the molecular pathogenesis of lung cancer. These tools include molecular and cellular biology and are starting to provide an insight into how the tumor cell, by altering oncogenes and tumor suppressor genes, achieves growth advantage, uncontrolled proliferation and metastatic behavior via disruption of key cell-cycle regulators and signal transduction cascades. Moreover, new knowledge is being developed in terms of the molecular definition of individual susceptibility to tobacco smoke carcinogens. These tools are being translated into clinical strategies to complement surgery, radiotherapy, and chemotherapy and also to assist in primary and secondary prevention efforts. This review summarizes current knowledge of the molecular pathogenesis of lung cancer, From this we know that respiratory epithelial cells require many genetic alterations to become invasive and metastatic cancer. We can detect cells with a few such changes in current and former smokers, offering the opportunity to intercede with abiomarker-monitored prevention and early detection effort. This will be coupled with new advances in computed tomography-based screening. Finally, because the molecular alterations are known, new mechanism-based therapies are being developed and brought to the clinic, including new drugs, vaccines,and gene therapy, which also must be integrated with standard therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:19:15