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Titolo:
Virus levels in untreated African infants infected with human immunodeficiency virus type 1
Autore:
Biggar, RJ; Janes, M; Pilon, R; Miotti, P; Taha, TET; Broadhead, R; Mtimivalye, L; Kumwenda, N; Cassol, S;
Indirizzi:
NIAID, Viral Epidemiol Branch, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 iral Epidemiol Branch, Bethesda, MD 20892 USA NIAID, AIDS Program, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892NIAID, AIDS Program, Bethesda, MD 20892 USA Johns Hopkins Sch Publ Hlth, Baltimore, MD USA Johns Hopkins Sch Publ Hlth Baltimore MD USA ubl Hlth, Baltimore, MD USA Ottawa Gen Hosp, Res Inst, Ottawa, ON K1H 8L6, Canada Ottawa Gen Hosp Ottawa ON Canada K1H 8L6 Inst, Ottawa, ON K1H 8L6, Canada Univ Malawi, Queen Elizabeth Cent Hosp, Sch Med, Blantyre, Malawi Univ Malawi Blantyre Malawi zabeth Cent Hosp, Sch Med, Blantyre, Malawi Johns Hopkins Minist Hlth Project, Blantyre, Malawi Johns Hopkins Minist Hlth Project Blantyre Malawi ect, Blantyre, Malawi
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 6, volume: 180, anno: 1999,
pagine: 1838 - 1843
SICI:
0022-1899(199912)180:6<1838:VLIUAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TO-CHILD TRANSMISSION; VIRAL LOAD; HIV-1 INFECTION; FILTER-PAPER; VERTICAL TRANSMISSION; RNA AMPLIFICATION; PLASMA; QUANTITATION; PROGRESSION; COUNT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Biggar, RJ 6130 Execut Blvd,EPN 434, Rockville, MD 20862 USA 6130 Execut Blvd,EPN 434 Rockville MD USA 20862 , MD 20862 USA
Citazione:
R.J. Biggar et al., "Virus levels in untreated African infants infected with human immunodeficiency virus type 1", J INFEC DIS, 180(6), 1999, pp. 1838-1843

Abstract

In developed areas, human immunodeficiency virus (HIV)-infected infants have high virus levels and rapidly progress to death. HIV levels were assessed in 1994-1997 in untreated infants in Malawi by analysis of dried blood spots tested by nucleic acid silica-bound amplification. Of 24 umbilical cordblood (CB)-positive samples, 83% had >10,000 copies/mL. The median virus level was 78,000 copies/mL. First positive sample median levels were 355,000copies/mL among 52 perinatally infected infants and 130,000 copies/mL among 43 infants infected by breast-feeding. Virus levels were stable, and initial levels predicted Levels 1 year after infection (P = .005), at which time levels did not significantly differ among in utero, perinatally, or postnatally infected infants. Thus, neither age at infection nor route of infection significantly influenced HIV levels measured 1 year after infection, Most (87%) CB-positive infants were infected before labor onset, since virus levels greatly exceeded those expected in their mothers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:02:20