Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Treatment with granulocyte colony-stimulating factor decreases the capacity of hematopoietic progenitor cells for generation of lymphocytes in human immunodeficiency virus-infected persons
Autore:
Nielsen, SD; Clark, DR; Hutchings, M; Dam-Larsen, S; Repping, S; Nielsen, JO; Mathiesen, L; Miedema, F; Hansen, JES;
Indirizzi:
Hvidovre Hosp, Infect Dis Lab, Dept Infect Dis, DK-2650 Hvidovre, Denmark Hvidovre Hosp Hvidovre Denmark DK-2650 ct Dis, DK-2650 Hvidovre, Denmark KAS Herlev, Dept Hematol, Herlev, Denmark KAS Herlev Herlev DenmarkKAS Herlev, Dept Hematol, Herlev, Denmark Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Clin Viroimmunol, Amsterdam, Netherlands Netherlands Red Cross Amsterdam Netherlands nol, Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 6, volume: 180, anno: 1999,
pagine: 1819 - 1826
SICI:
0022-1899(199912)180:6<1819:TWGCFD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW CELLS; MOBILIZED PERIPHERAL-BLOOD; GENE-THERAPY; T-CELLS; STEM-CELLS; IN-VIVO; MYELOID DIFFERENTIATION; ANTIRETROVIRAL THERAPY; HIV-1 REPLICATION; CANCER-PATIENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Nielsen, SD Hvidovre Hosp, Infect Dis Lab, Dept Infect Dis, 144, DK-2650 Hvidovre, Denmark Hvidovre Hosp 144 Hvidovre Denmark DK-2650 Hvidovre, Denmark
Citazione:
S.D. Nielsen et al., "Treatment with granulocyte colony-stimulating factor decreases the capacity of hematopoietic progenitor cells for generation of lymphocytes in human immunodeficiency virus-infected persons", J INFEC DIS, 180(6), 1999, pp. 1819-1826

Abstract

An obstacle to stem cell gene therapy for AIDS is the limited numbers of hematopoietic progenitors available. Granulocyte colony-stimulating factor (G-CSF) is used for mobilization of progenitors, but little is known about the functional characteristics of mobilized progenitors, and immature and T cell progenitors may not be mobilized. This study examined the effect of G-CSF on the function of progenitors. Ten human immunodeficiency virus-infected patients received G-CSF (filgrastim, 300 mu g/day) for 5 days. Absolute numbers of immature and T cell progenitors did not increase. The ability ofCD34(+) progenitor cells to generate lymphocytes was examined by use of thymic organ cultures. The mean number of lymphocytes generated per CD34(+) cell on day 0 was 0.72 and on day 4 was 0.09 (P < .003), The number of CD4(+) cells generated per CD34(+) cell was significantly reduced after G-CSF treatment. Thus, G-CSF increased the number of mature progenitor cells but did not increase T cell progenitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:32:23