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Titolo:
Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases
Autore:
Kurata, T; Oguri, T; Isobe, T; Ishioka, S; Yamakido, M;
Indirizzi:
Hiroshima Univ, Fac Med, Dept Internal Med 2, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 11, volume: 90, anno: 1999,
pagine: 1238 - 1243
SICI:
0910-5050(199911)90:11<1238:DEOFGT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; PROTEIN MRP; SEQUENCE; CELL; LOCALIZATION; RESISTANCE; TISSUES; OVEREXPRESSION; CARCINOMAS; CLONING;
Keywords:
GLUT1; GLUT3; GLUT5; lung cancer; metastatic lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Isobe, T Hiroshima Univ, Fac Med, Dept Internal Med 2, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan7348551 48551, Japan
Citazione:
T. Kurata et al., "Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases", JPN J CANC, 90(11), 1999, pp. 1238-1243

Abstract

Glucose uptake is mediated by members of the facilitative glucose transporter (GLUT) family, Malignant cells take up more glucose than their normal counterparts. The aim of this study; was to investigate the gene expression levels of the GLUT family, especially GLUT1, GLUT3, and GLUT5 in primary lung cancer, metastatic liver tumors, and normal lung tissues, and to comparethe expression levels of primary and metastatic tumors with those of normal tissues. We analyzed 105 autopsy. samples (35 primary lung tumors, 35 corresponding normal lung tissues, 25 normal Liver tissues, and 10 metastatic Liver tumors) from 35 patients using the quantitative reverse transcriptionpolymerase chain reaction. The GLUT1 gene expression levels in primary lung tumors a were significantly higher than those in normal lung tissues, In liver metastatic lesions, the GLUT3 and GLUT5 gene expression levels were significantly higher than these in primary lung tumors, but there were no differences in GLUT1 expression levels between primary and metastatic liver tumors, Our results show that the gene expression pattern of the GLUT familyis different between primary and metastatic Liver tumors and suggest that the energy transporters in metastatic tumors may be different from those inprimary tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:46:48