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Titolo:
Brain event-related potentials (ERPs) in schizophrenia during a word recognition memory task
Autore:
Kayser, J; Bruder, GE; Friedman, D; Tenke, CE; Amador, XF; Clark, SC; Malaspina, D; Gorman, JM;
Indirizzi:
New York State Psychiat Inst, Dept Biopsychol, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA New York State Psychiat Inst, Dept Med Genet, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA New York State Psychiat Inst, Dept Clin Psychobiol, New York, NY 10032 USANew York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
fascicolo: 3, volume: 34, anno: 1999,
pagine: 249 - 265
SICI:
0167-8760(199912)34:3<249:BEP(IS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR TEMPORAL GYRUS; FIRST-EPISODE SCHIZOPHRENIA; MAGNETIC-RESONANCE; CEREBRAL ASYMMETRY; LIMBIC DYSFUNCTION; PLANUM TEMPORALE; VOLUME REDUCTION; THOUGHT-DISORDER; LOBE; ABNORMALITIES;
Keywords:
schizophrenia; word recognition memory; ERP repetition effect; ERP asymmetry; N2-P3 complex; principal components analysis (PCA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Kayser, J New York State Psychiat Inst, Dept Biopsychol, 1051 Riverside Dr, New York, NY 10032 USA New York State Psychiat Inst 1051 Riverside Dr NewYork NY USA 10032
Citazione:
J. Kayser et al., "Brain event-related potentials (ERPs) in schizophrenia during a word recognition memory task", INT J PSYCP, 34(3), 1999, pp. 249-265

Abstract

Impairments of recognition memory for. words and attenuation of the ERP 'old-new' effect have been found in patients with left medial temporal lobe damage. If left temporal lobe dysfunction in schizophrenia involves medial structures (e.g. hippocampus), then schizophrenic patients might show similar abnormalities of verbal recognition memory. This study recorded ERPs from30 electrode sites while subjects were engaged in a continuous word recognition memory task. Results are reported for 24 patients having a diagnosis of schizophrenia (n = 16) or schizoaffective disorder (n = 8) and 19 age-matched healthy controls. Both patients and controls showed the expected 'old-new' effect, with greater late positivity to correctly recognized old words at posterior sites, and there was also no significant difference between groups in P3 amplitude. However, accuracy of word recognition memory was poorer in patients than controls, and patients showed markedly smaller N2 amplitude. Reduced amplitudes of N2 and N2-P3 were associated with poorer performance, with highest correlations over the left inferior parietal (N2) andleft medial parietal (N2-P3) region. Moreover, patients failed to show significantly greater left than right hemisphere amplitude of N2-P3 at posterior sites, which was seen for healthy controls. These findings suggest that impaired word recognition in schizophrenia may arise from a left lateralized deficit at an early stage of processing, beginning at 200-300 ms after word onset. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 19:01:08