Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regional differentiation of neuron morphology in human left and right hippocampus: comparing normal to schizophrenia
Autore:
Zaidel, DW;
Indirizzi:
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA Univ CalifLos Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
fascicolo: 3, volume: 34, anno: 1999,
pagine: 187 - 196
SICI:
0167-8760(199912)34:3<187:RDONMI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-RIGHT ASYMMETRY; SIZE; LANGUAGE; DENSITY;
Keywords:
morphogenesis; brain hemispheres; neuron size; neuron form; memory; brain asymmetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Zaidel, DW Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 , CA 90024 USA
Citazione:
D.W. Zaidel, "Regional differentiation of neuron morphology in human left and right hippocampus: comparing normal to schizophrenia", INT J PSYCP, 34(3), 1999, pp. 187-196

Abstract

Regional differentiation based on size, form, and orientation angle of thesoma of individual neurons in human post-mortem hippocampus was determinedthrough correlations between pairs of hippocampal subfields in each side separately. The neurons were previously measured on a computer. In the normal cases, a left-right asymmetrical pattern of regional differentiation based on soma size emerged, while for form and orientation angle, the patterns appeared symmetrical. In schizophrenia, regional soma size, form, and orientation variability were expressed largely symmetrically. Regional correlations based on neuronal density revealed an asymmetrical hemispheric pattern in the normal cases versus a nearly symmetrical pattern in schizophrenia. Taken together, the inter-regional correlations favor a hippocampal landscape that deviates in each side from connectivity based on the canonical trisynaptic hippocampal circuitry. It is proposed that during morphogenesis, rudimentary inter-regional networks are formed through specific interactions between regional neurons; these networks are present in the adult hippocampus and may be vulnerable in brain diseases. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:40:00