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Titolo:
An investigation into the use of micro-thermal analysis for the solid state characterisation of an HPMC tablet formulation
Autore:
Royall, PG; Craig, DQM; Price, DM; Reading, M; Lever, TJ;
Indirizzi:
Univ London, Sch Pharm, Ctr Mat Sci, London WC1N 1AX, England Univ LondonLondon England WC1N 1AX tr Mat Sci, London WC1N 1AX, England Univ Loughborough, IPTME, Loughborough LE11 3TU, Leics, England Univ Loughborough Loughborough Leics England LE11 3TU 3TU, Leics, England TA Instruments, Bilton Ctr, Leatherhead KT22 7UQ, Surrey, England TA Instruments Leatherhead Surrey England KT22 7UQ 2 7UQ, Surrey, England
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1, volume: 192, anno: 1999,
pagine: 97 - 103
SICI:
0378-5173(199912)192:1<97:AIITUO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Keywords:
atomic force microscopy; micro-thermal analysis; hydroxypropyl methylcellulose; ibuprofen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Royall, PG Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL,Antrim, North Ireland Queens Univ Belfast 97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
P.G. Royall et al., "An investigation into the use of micro-thermal analysis for the solid state characterisation of an HPMC tablet formulation", INT J PHARM, 192(1), 1999, pp. 97-103

Abstract

The use of micro-thermal analysis (mu TA(TM)) as a novel means of differentiating between components in a model tablet formulation is described. Thistechnique involves a modification of atomic force microscopy (AFM) such that the standard AFM tip is replaced with a Wollaston wire, thereby allowingthe probe to act as a thermistor and temperature probe. Consequently it ispossible to map not only the topology but also the thermal conductivity ofthe sample. Furthermore, it is possible to apply a heating signal to the material and thereby to perform thermal analysis on highly localised regionsof the sample. Compacts were prepared comprising ibuprofen, HPMC E4M prem and 1:1 mixes of the two components and analysed using a mu TA(TM) micro-thermal analyser. The surface topology and conductivity images of the three systems are reported. In addition, the ability of the technique to perform thermal analysis on highly specific regions of the sample is described. The method was able to differentiate between the components of the sample on the basis of micro-thermomechanical experiments. The implications of the use of the technique for the study of pharmaceutical tablets is discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:07:49