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Titolo:
The effects of experimental parameters and calibration on MTDSC data
Autore:
Hill, VL; Craig, DQM; Feely, LC;
Indirizzi:
Univ London, Sch Pharm, Ctr Mat Sci, London WC1N 1AX, England Univ LondonLondon England WC1N 1AX tr Mat Sci, London WC1N 1AX, England Abbott Labs, Int Dev Ctr, Queenborough ME11 5EL, Kent, England Abbott Labs Queenborough Kent England ME11 5EL gh ME11 5EL, Kent, England
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1, volume: 192, anno: 1999,
pagine: 21 - 32
SICI:
0378-5173(199912)192:1<21:TEOEPA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENTIAL SCANNING CALORIMETRY; HEAT-CAPACITY MEASUREMENT; MODULATED DSC; GLASS-TRANSITION; TEMPERATURE;
Keywords:
calibration; experimental parameters; heat capacity; modulation; MTDSC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Craig, DQM Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL,Antrim, North Ireland Queens Univ Belfast 97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
V.L. Hill et al., "The effects of experimental parameters and calibration on MTDSC data", INT J PHARM, 192(1), 1999, pp. 21-32

Abstract

To produce accurate and artefact-free MTDSC data it is necessary to choosesuitable experimental parameters (i.e. modulation period, temperature amplitude, sample mass and pan type). A poor choice of parameters can result indistortion of the modulation and inaccurate heat capacity data and can also affect the result of the deconvolution procedure. This paper aims to review these effects and to offer some guidance on how to achieve optimum results. In particular, it is suggested that the modulation parameters should bechosen to ensure that the sample can follow the programme without thermal gradients developing and also that at least six modulations should take place during any thermal transition. Two methods of calibration are discussed;a one-point method is sufficient in most cases but a temperature-dependentmethod should be used when more accurate data are required or for sub-ambient experiments. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:01:03