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Titolo:
Allelic diversity at class II DRB1 and DQB loci of the pig MHC (SLA)
Autore:
Kanai, TH; Tanioka, Y; Tanigawa, M; Matsumoto, Y; Ueda, S; Onodera, T; Matsumoto, Y;
Indirizzi:
Univ Tokyo, Sch Agr & Life Sci, Dept Mol Immunol, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 Immunol, Bunkyo Ku, Tokyo 1138657, Japan Cent Inst Expt Anim, Miyamae Ku, Kawasaki, Kanagawa 2160001, Japan Cent Inst Expt Anim Kawasaki Kanagawa Japan 2160001 nagawa 2160001, Japan SLA RES Inc, Nagano 3920016, Japan SLA RES Inc Nagano Japan 3920016SLA RES Inc, Nagano 3920016, Japan Nippon Inst Biol Sci, Tokyo 1980024, Japan Nippon Inst Biol Sci Tokyo Japan 1980024 Biol Sci, Tokyo 1980024, Japan
Titolo Testata:
IMMUNOGENETICS
fascicolo: 5-6, volume: 50, anno: 1999,
pagine: 295 - 300
SICI:
0093-7711(199912)50:5-6<295:ADACID>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINIATURE SWINE; POLYMORPHISM; EVOLUTION; GENES; EXCHANGE; DNA; RECOMBINATION; GENERATION; PRIMATES; MOTIFS;
Keywords:
MHC class II; generation of diversity; SLA-DRB1; SLA-DQB sequence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, Y Univ Tokyo, Sch Agr & Life Sci, Dept Mol Immunol, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan 1138657 yo 1138657, Japan
Citazione:
T.H. Kanai et al., "Allelic diversity at class II DRB1 and DQB loci of the pig MHC (SLA)", IMMUNOGENET, 50(5-6), 1999, pp. 295-300

Abstract

The loci encoding the beta chain of the pig major histocompatibility complex (MHC) class II antigens, SLA-DR and -DQ, have been known to exhibit a remarkable degree of allelic polymorphism. Here, to understand the generationof SLA class II polymorphism, 25 SLA-DRB1 and 24 SLA-DQB genes including newly identified 12 SLA-DRB1 and 7 SLA-DQB genes obtained from miniature pigs were analyzed based on the nucleotide and deduced amino acid sequences. Most of the allelic diversity was attributed to the variable sequences whichencode a beta(1) domain consisting of a beta-pleated sheet followed by an alpha helix. In the beta(1) domain coding region, there were four GC-rich sequences, which have been considered to involve the intra-exon sequence exchange also in other gene evolutions. The first and second GC-rich sequenceswere X-like sequences, which have been shown to be a putative recombination signal, and were stably conserved among SLA-DRB1 and DQB genes. These X-like sequences identified in SLA-DRB1 and SLA-DQB were found to encode the first turning point of the beta-pleated sheet and the boundary between the beta-pleated sheet and the alpha helix. Analysis of clustered sequence variation also suggested intra-exon gene conversions in which the chi-like sequences act as putative breakpoints. In addition to point mutations and selection mechanism, intra-exon gene conversions must be an important mechanism in the generation of allelic polymorphism at the SLA-DRB1 and SLA-DQB.

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Documento generato il 02/04/20 alle ore 06:37:34