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Titolo:
SD3212, a new antiarrhythmic drug, raises atrial fibrillation threshold inisolated rabbit hearts
Autore:
Matsuo, R; Shirayama, T; Inoue, K; Matoba, Y; Imai, H; Shiraishi, H; Tatsumi, T; Nakagawa, M;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
HEART AND VESSELS
fascicolo: 3, volume: 14, anno: 1999,
pagine: 127 - 136
SICI:
0910-8327(1999)14:3<127:SANADR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA++ CHANNEL BLOCKER; SD-3212; ACETYLCHOLINE; THERAPY; AGENT; DISOPYRAMIDE; FLECAINIDE; MANAGEMENT; AMIODARONE; BEPRIDIL;
Keywords:
antiarrhythmic drug; SD3212; atrial fibrillation; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Shirayama, T Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 28566, Japan
Citazione:
R. Matsuo et al., "SD3212, a new antiarrhythmic drug, raises atrial fibrillation threshold inisolated rabbit hearts", HEART VESS, 14(3), 1999, pp. 127-136

Abstract

SD3212 is a new antiarrhythmic drug which has class I, III, and IV effects. The purpose of this study was to elucidate the electrophysiological effects of this compound on a rabbit atrial fibrillation model, and to test a hypothesis that atrial fibrillation threshold is a quantitative indicator of atrial vulnerability. Whole hearts were excised from rabbits, and the aortas cannulated to perfuse the coronary arteries. Atrial fibrillation was induced with a burst stimulation of 50 Hz for 1 s while 3 mu M acetylcholine (ACh) was perfused. When the right atrial appendage was paced at 200-ms intervals, SD3212 prolonged interatrial conduction time: control 30 +/- 1.2 ms, ACh 33 +/- 1.4 ms, ACh +/- SD 1 mu M 37 +/- 2.4 ms, ACh + SD 3 mu M 52 +/- 8.1 ms. The drug also prolonged the effective refractory period: control 80+/- 3.0 ms, ACh 48 +/- 3.5 ms, ACh + SD 1 mu M 65 +/- 4.7 ms, ACh + SD 3 mu M 98 +/- 15 ms, The rate of induction of atrial fibrillation by rapid pacing was 26% in Tyrode's solution, 85% in the presence of ACh, and 38% in the presence of ACh + SD 1 mu M. The atrial fibrillation threshold decreased from 8.6 +/- 0.8 mA (control) to 2.5 +/- 0.7mA in the presence of ACh. It increased again to 7.8 +/- 1.0 mA in the presence of SD3212 (1 mu M). SD3212prolonged both the conduction time and refractory period. A reversed use-dependency was not prominent. These features caused antifibrillatory effects. Thus, the atrial fibrillation threshold seems to be a good quantitative indicator of atrial vulnerability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:55:29