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Titolo:
DIFFERENT LIFE-STYLES OF HUMAN PATHOGENIC PROKARYOTES AND THEIR STRATEGIES FOR PHASE AND ANTIGENIC VARIATION
Autore:
FUSSENEGGER M;
Indirizzi:
ETH HONGGERBERG,INST BIOTECHNOL,HPT CH-8093 ZURICH SWITZERLAND
Titolo Testata:
Symbiosis
fascicolo: 1-2, volume: 22, anno: 1997,
pagine: 85 - 153
SICI:
0334-5114(1997)22:1-2<85:DLOHPP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-MEMBRANE PROTEIN; INFLUENZAE TYPE-B; ENTEROPATHOGENIC ESCHERICHIA-COLI; HUMAN EPITHELIAL-CELLS; TISSUE-CULTURE CELLS; GROUP-A STREPTOCOCCI; HUMAN MUCOSAL CELLS; TRANSPOSON SHUTTLE MUTAGENESIS; COMPLETE NUCLEOTIDE-SEQUENCE; FIBRONECTIN-BINDING PROTEIN;
Keywords:
HOST-PATHOGEN INTERACTION; BACTERIAL INFECTION; VIRULENCE FACTORS; TOXIN; EPITHELIAL CELL INVASION; IMMUNE ESCAPE; GENETIC VARIATION; PILUS; LPS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
339
Recensione:
Indirizzi per estratti:
Citazione:
M. Fussenegger, "DIFFERENT LIFE-STYLES OF HUMAN PATHOGENIC PROKARYOTES AND THEIR STRATEGIES FOR PHASE AND ANTIGENIC VARIATION", Symbiosis, 22(1-2), 1997, pp. 85-153

Abstract

Bacteria generally cause disease in a mammalian host by a multifacetted process involving numerous components, each one of which may be necessary for pathogenesis. These virulence determinants include a variety of factors that enable colonization of a specific niche in the host,evasion of host immune responses, invasion of mammalian tissues and/or cells, or direct host toxicity. The mechanisms used by pathogenic bacteria to cause infection and disease are diverse, but they usually include a co-regulated group of complementary genetic properties that are best suited for the interaction of a particular microorganism with aparticular host. However, because of their need to overcome similar host and environmental barriers, common themes of microbial pathogenesis have evolved in quite distinct bacterial species. We describe here four different but rather general strategies of host-pathogen interactions and outline the crosstalks which take place at the molecular levelduring different stages of an infection. Because they deal with various microenvironments during the course of infection, most bacterial pathogens evolved different mechanisms for generating genetic variation. The ability to vary their cell-surface composition may often play a key role in the evasion of antigen-specific host immune defences. In addition, it may promote expression of the most appropriate cell-surfacestructures for a given microenvironment or infection stage, thereby optimizing the virulence potential of a bacterial pathogen during the course of infection. Here we review, in the context of the corresponding infection processes, mechanisms that bring about this antigenic and phase variation as well as its functional consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:47:20