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Titolo:
The role of nitric oxide in mediating pancreatic endocrine responses to insulin-induced hypoglycaemia in the conscious calf
Autore:
Edwards, CMB; Ghatei, MA; Bloom, SR; Edwards, AV;
Indirizzi:
Univ Cambridge, Physiol Lab, Cambridge CB2 3EG, England Univ Cambridge Cambridge England CB2 3EG Lab, Cambridge CB2 3EG, England Hammersmith Hosp, ICSM, Endocrine Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN ne Unit, London W12 0NN, England
Titolo Testata:
EXPERIMENTAL PHYSIOLOGY
fascicolo: 6, volume: 84, anno: 1999,
pagine: 1107 - 1113
SICI:
0958-0670(199911)84:6<1107:TRONOI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE METHYL-ESTER; ACETYLCHOLINE-RELEASE; SECRETION; SYNTHASE; GLUCOSE; EXOCRINE; GLUCAGON; CYCLASE; SYSTEM; ISLETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Edwards, AV Univ Cambridge, Physiol Lab, Downing St, Cambridge CB2 3EG, England Univ Cambridge Downing St Cambridge England CB2 3EG , England
Citazione:
C.M.B. Edwards et al., "The role of nitric oxide in mediating pancreatic endocrine responses to insulin-induced hypoglycaemia in the conscious calf", EXP PHYSIOL, 84(6), 1999, pp. 1107-1113

Abstract

The role of nitric oxide (NO) in mediating pancreatic endocrine responses to moderate hypoglycaemia has been investigated in conscious unrestrained calves. The synthesis of endogenous NO was inhibited by the administration of N-nitro-L-arginine methyl eater (L-NaME; 100 mg kg(-1) I.A.), while sodium nitroprusside was infused continuously (2-4 mu g min(-1) kg(-1) I.V.) to mimic the tonic production of NO. This effectively abolished the rise in plasma pancreatic polypeptide (PP) concentration during moderate hypoglycaemia (0.7 nmol kg(-1) insulin I.V.) and significantly reduced the response to more intense hypoglycaemia (2.0 nmol kg(-1) insulin I.V.). In contrast, theglucagon response was not significantly affected in either group, althoughconsistently higher plasma glucagon values were obtained in response to the higher dose of insulin following the administration of L-NAME. It is concluded that, in the absence of L-NAME, production of NO contributes to the PP response, but not the glucagon response to hypoglycaemia in this species under physiological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:15:48