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Titolo:
Dopamine D-2 receptor antagonists prevent Delta(9)-tetrahydrocannabinol-induced antinociception in rats
Autore:
Carta, G; Gessa, GL; Nava, F;
Indirizzi:
Neurosci SCARL, Cagliari, Italy Neurosci SCARL Cagliari ItalyNeurosci SCARL, Cagliari, Italy Univ Cagliari, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 t Neurosci, I-09124 Cagliari, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 384, anno: 1999,
pagine: 153 - 156
SICI:
0014-2999(19991119)384:2-3<153:DDRAPD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CB1 RECEPTORS; CANNABINOIDS;
Keywords:
analgesia; Delta(9)-tetrahydrocannabinol; SR 141716A; S(-)-sulpiride; S(-)-raclopride; (-)-quinpirole; (+)-bromocriptine; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Gessa, GL Neurosci SCARL, Cagliari, Italy Neurosci SCARL Cagliari ItalyNeurosci SCARL, Cagliari, Italy
Citazione:
G. Carta et al., "Dopamine D-2 receptor antagonists prevent Delta(9)-tetrahydrocannabinol-induced antinociception in rats", EUR J PHARM, 384(2-3), 1999, pp. 153-156

Abstract

Delta(9)-Tetrahydrocannabinol (1 and 5 mg/kg, i.p.) produced, dose-dependently, antinociceptive effects using hot plate and tail flick tests in rats. These effects were suppressed not only by the cannabinoid CB1 receptor antagonist SR 141716A (0.5 mg/kg; i.p.) but also by the dopamine D-2 receptor antagonists S(-)-sulpiride (5 and 10 mg/kg; i.p.) and S(-)-raclopride (1.5 and 3 mg/kg; i.p.). Conversely, Delta(9)-tetrahydrocannabinol antinociceptive effects were potentiated by the dopamine D-2 receptor agonists (-)-quinpirole (0.025 mg/kg, s.c.) and (+)-bromocriptine (0.5 and 1 mg/kg; i.p.). Our results indicate that the antinociceptive effects of Delta(9)-tetrahydrocannabinol are mediated by the concomitant activation of cannabinoid CB1 anddopamine D-2 receptors and that dopamine D-2 receptor agonists may be useful in improving the analgesic effects of cannabinoids. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 20:37:26