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Titolo:
Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats
Autore:
Lorenc-Koci, E; Wolfarth, S;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Neurophychopharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 385, anno: 1999,
pagine: 39 - 46
SICI:
0014-2999(19991126)385:1<39:EOPAND>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; D-2; CATALEPSY; MODEL; TONE;
Keywords:
dopamine receptor agonist; electromyogram; mechanomyogram; muscle rigidity; parkinsonism; pramipexole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Lorenc-Koci, E Polish Acad Sci, Inst Pharmacol, Dept Neurophychopharmacol,12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St KrakowPoland PL-31343 Poland
Citazione:
E. Lorenc-Koci e S. Wolfarth, "Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats", EUR J PHARM, 385(1), 1999, pp. 39-46

Abstract

The aim of the present study was to assess the efficacy of pramipexole (2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochloride), a new dopamine D-2/D-3 receptor agonist, to attenuate parkinsonian-like muscle rigidity in rats. Muscle tone was examined using a combined mechano- and electromyographic (EMG) method, which simultaneously measured the muscle resistance of a rat's hindlimb to passive extension and flexion at the ankle joint, and the EMG activity of the antagonistic muscles of that joint: gastrocnemius and tibialis anterior. Muscle rigidity was produced by reserpine (5mg/kg) injected in combination with alpha-methyl-p-tyrosine (250 mg/kg) orby haloperidol (0.5 mg/kg). Pramipexole in doses of 0.5-5 mg/kg antagonized both reserpine +alpha-methyl-p-tyrosine- and haloperidol-induced muscle rigidity. Pramipexole also reduced reserpine-enhanced tonic and reflex EMG activities in the gastrocnemius muscle. The present results suggest that stimulation of the postsynaptic dopamine receptor may be chiefly responsible for the antiparkinsonian action of pramipexole. The ability of pramipexole to diminish the parkinsonian-like muscle rigidity seems to indicate a therapeutic value of this compound in the treatment of Parkinson's disease. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:38:38