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Titolo:
Searching for a general anaesthesia protocol for rapid detoxification fromopioids
Autore:
Lorenzi, P; Marsili, M; Boncinelli, S; Fabbri, LP; Fontanari, P; Zorn, AM; Mannaioni, PF; Masini, E;
Indirizzi:
Univ Florence, Careggi Gen Hosp, Univ Anaesthesia & Intens Care, Dept ClinPhysiopathol, Florence, Italy Univ Florence Florence Italy re, Dept ClinPhysiopathol, Florence, Italy
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 10, volume: 16, anno: 1999,
pagine: 719 - 727
SICI:
0265-0215(199910)16:10<719:SFAGAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONINVASIVE OPIATE DETOXIFICATION; LONG-TERM SEDATION; WITHDRAWAL SYMPTOMS; PROPOFOL INFUSION; MIDAZOLAM; ANESTHESIA; NALOXONE; METHOHEXITONE; ADDICTION;
Keywords:
anaesthetic techniques, midazolam, propofol; ultrarapid opioid detoxification, naloxone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lorenzi, P Policlin Careggi, Sez Anestesia & Rianimaz, Dipartimento Fisiopatol Clin, Viale Morgagni 85, I-50134 Florence, Italy Policlin Careggi Viale Morgagni 85 Florence Italy I-50134 taly
Citazione:
P. Lorenzi et al., "Searching for a general anaesthesia protocol for rapid detoxification fromopioids", EUR J ANAES, 16(10), 1999, pp. 719-727

Abstract

The technique for ultra rapid opioid detoxification is designed to shortenthe detoxification period by precipitating withdrawal by the administration of opioid antagonists such as naloxone or naltrexone. This procedure is performed under deep sedation or general anaesthesia to ensure that the patient does not consciously experience the acute withdrawal phase. This strategy has aroused controversy regarding the risk of sedation or anaesthesia inthis situation. In the present study, ultra rapid opioid detoxification was carried out in 12 opiate-addicted patients by infusion of naloxone 4 mg for a period of 5 h using controlled ventilation during general anaesthesia,induced and maintained with midazolam, propofol and atracurium. Invasive cardiovascular and respiratory monitoring was performed, and withdrawal signs were evaluated using a graduated scale. Anaesthesia was maintained for another hour after the completion of the naloxone infusion. The validity of this anaesthesia protocol was confirmed by the relative lack of change in the patients' haemodynamic values associated with mild signs of withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:42:57