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Titolo:
Effects of endothelin-1 on bacterial clearance in rabbits
Autore:
Schmeck, J; Heller, A; Phan, TLH; Urbschek, R; Koch, T;
Indirizzi:
Univ Heidelberg, Univ Hosp, Fac Clin Med Mannheim, Dept Anaesthesiol & Intens Care Med, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 Med, D-68135 Mannheim, Germany Univ Heidelberg, Univ Hosp, Fac Clin Med Mannheim, Dept Med Microbiol & Hyg, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 Hyg, D-68135 Mannheim, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 3, volume: 16, anno: 1999,
pagine: 169 - 175
SICI:
0265-0215(199903)16:3<169:EOEOBC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; TUMOR-NECROSIS-FACTOR; VASOCONSTRICTOR PEPTIDE; SEPSIS; CELLS; INVOLVEMENT; HEMORRHAGE; LUNG; RAT;
Keywords:
experimental, rabbit, bacterial clearance, endothelin-1, sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Schmeck, J Univ Heidelberg, Univ Hosp, Fac Clin Med Mannheim, Dept Anaesthesiol & Intens Care Med, Theodor Kutzer Ufer, D-68135 Mannheim, Germany Univ Heidelberg Theodor Kutzer Ufer Mannheim Germany D-68135 y
Citazione:
J. Schmeck et al., "Effects of endothelin-1 on bacterial clearance in rabbits", EUR J ANAES, 16(3), 1999, pp. 169-175

Abstract

As elevated endothelin-1 (ET-1) levels have been reported in systemic inflammatory diseases, the role of ET-1 as a promoter of inflammatory reactionsis currently under investigation. The purpose of this study was to investigate the potential influence of ET-1 on systemic vascular pressure and immune function in terms of blood clearance and organ distribution of injected Escherichia coli in a rabbit model. To enable quantification of the clearance process, defined numbers of exogenous E. coli (10(8) cfu) were injected intravenously 60 min after starting the infusion of ET-1 (0.2 mu g kg(-1) min(-1); n=9) or after saline infusion (controls, n=9). Parameters monitoredwere arterial blood pressure, airway pressure, serum lactate concentrations and rates of bacterial elimination from the blood. At 180 min after E. coli injection, the animals were killed, and tissue samples of liver, kidney,spleen and lung were collected for bacterial counts. ET-1 infusion produced an increase in mean arterial pressure (83.9 +/- 3.9 mmHg vs. 50.1 +/- 4.1mmHg at 120 min; P < 0.01) associated with higher serum lactate concentrations (12.6 +/- 1.3 vs. 5.4 +/- 0.3 mg dL(-1); P < 0.001) and a delayed bacterial elimination from the blood compared with controls. Furthermore, therewas increased colonization of the lungs (3.6 +/- 0.5x10(3) cfu vs. 745 +/-120 cfu; P < 0.01), spleen (142.4 +/- 45.4x10(3) cfu vs. 22.7 +/- 5.2x10(3) cfu; P < 0.05) and kidney (758 +/- 329 vs. 357 +/- 151 cfu; NS), reflecting a reduced bacterial killing function.

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Documento generato il 04/04/20 alle ore 12:20:01