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Titolo:
Comparison of ondansetron and tropisetron combined with droperidol for theprevention of emesis in women with a history of post-operative nausea and vomiting
Autore:
Koivuranta, A; Ala-Kokko, TI; Jokela, R; Ranta, P;
Indirizzi:
Oulu Univ Hosp, Dept Anaesthesiol, FIN-90220 Oulu, Finland Oulu Univ HospOulu Finland FIN-90220 esthesiol, FIN-90220 Oulu, Finland
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 6, volume: 16, anno: 1999,
pagine: 390 - 395
SICI:
0265-0215(199906)16:6<390:COOATC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC ANTIEMETIC THERAPY; POSTOPERATIVE NAUSEA; LAPAROSCOPIC CHOLECYSTECTOMY; GYNECOLOGICAL SURGERY; DOUBLE-BLIND; PLACEBO; GRANISETRON; COMBINATION; EFFICACY;
Keywords:
complications, nausea, vomiting; antiemetics, ondansetron, tropisetron; surgery, laparoscopic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Koivuranta, A Oulu Univ Hosp, Dept Anaesthesiol, Kajaanintie 50, FIN-90220Oulu, Finland Oulu Univ Hosp Kajaanintie 50 Oulu Finland FIN-90220 inland
Citazione:
A. Koivuranta et al., "Comparison of ondansetron and tropisetron combined with droperidol for theprevention of emesis in women with a history of post-operative nausea and vomiting", EUR J ANAES, 16(6), 1999, pp. 390-395

Abstract

The anti-emetic efficacy of prophylactic ondansetron and tropisetron in combination with a low dose of droperidol in patients with high probability for post-operative nausea and vomiting undergoing gynaecological laparoscopywas compared. Patients were randomly allocated in a double-blind manner toreceive either ondansetron 8 mg (n=45) or tropisetron 5 mg (n=43) at the end of surgery. A standardized general anaesthetic technique was used, including droperidol 0.75 mg. The incidence of nausea was 36% and 49% (P=0.28), and vomiting occurred in 13% and 14% of the patients in the ondansetron andtropisetron groups, respectively. The onset time for rescue medication wassignificantly sooner after tropisetron than ondansetron (3 h 18min vs. 6 h25min; P=0.007). There were no statistically significant differences in efficacy between prophylactic ondansetron and tropisetron combined with droperidol in a high-risk population. However, ondansetron appeared to be more effective in preventing post-operative nausea and vomiting in the early hours after surgery compared with tropisetron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:51:50