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Titolo:
The influence of several intravenous anaesthetics on the chemotaxis of human monocytes in vitro
Autore:
Krumholz, W; Reussner, D; Hempelmann, G;
Indirizzi:
Univ Giessen, Dept Anaesthesiol & Intens Care Med, Giessen, Germany Univ Giessen Giessen Germany hesiol & Intens Care Med, Giessen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 8, volume: 16, anno: 1999,
pagine: 547 - 549
SICI:
0265-0215(199908)16:8<547:TIOSIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIC AGENTS; PHARMACOKINETICS;
Keywords:
intravenous anaesthetics, chemotaxis, monocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Krumholz, W Bethlehem Krankenhaus, Anaesthesiol & Operat Intens Med Abt, Steinfeldstr 5, D-52222 Stolberg, Germany Bethlehem Krankenhaus Steinfeldstr5 Stolberg Germany D-52222
Citazione:
W. Krumholz et al., "The influence of several intravenous anaesthetics on the chemotaxis of human monocytes in vitro", EUR J ANAES, 16(8), 1999, pp. 547-549

Abstract

Monocytes play a very important part in humoral as well as in cell-mediated immunity. At present, however, the knowledge of the influence of anaesthetic agents on the functions of monocytes is limited. In the present study, the effects of thiopentone, methohexitone, ketamine, midazolam, droperidol,propofol, etomidate, and fentanyl on monocyte chemotaxis were examined in vitro using a 48-well microchemotaxis chamber. Clinically relevant concentrations of ketamine, midazolam, and droperidol significantly (P less than orequal to 0.05) inhibited chemotaxis. For that reason, it is possible that these anaesthetics impair the immunological system in vivo. This possibility should be further examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 14:05:53