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Titolo:
Seizures induced by penicillin microinjections in the mesencephalic tegmentum
Autore:
Jimenez, F; Velasco, F; Carrillo-Ruiz, J; Villanueva, FE; Velasco, M; Ponce, H;
Indirizzi:
Gen Hosp, Neurol Unit, Mexico City, DF, Mexico Gen Hosp Mexico City DF Mexico osp, Neurol Unit, Mexico City, DF, Mexico Gen Hosp, Neurosurg Unit, Mexico City, DF, Mexico Gen Hosp Mexico City DFMexico , Neurosurg Unit, Mexico City, DF, Mexico Childrens Hosp SS, Mexico City, DF, Mexico Childrens Hosp SS Mexico City DF Mexico Hosp SS, Mexico City, DF, Mexico Natl Med Ctr IMSS, Dept Med Res, Mexico City, DF, Mexico Natl Med Ctr IMSS Mexico City DF Mexico Med Res, Mexico City, DF, Mexico
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 1, volume: 38, anno: 2000,
pagine: 33 - 44
SICI:
0920-1211(200001)38:1<33:SIBPMI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCORTICAL STRUCTURES; EPILEPTIFORM ACTIVITY; SUBSTANTIA-NIGRA; FOCAL EPILEPSY; CAT; PATHOPHYSIOLOGY; NEOCORTEX; SPIKES;
Keywords:
brain stem; EEG; multiple unit recording; penicillin; reticular formation; seizure pattern;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Velasco, F Gen Hosp, Neurol Unit, Mexico City, DF, Mexico Gen Hosp MexicoCity DF Mexico Unit, Mexico City, DF, Mexico
Citazione:
F. Jimenez et al., "Seizures induced by penicillin microinjections in the mesencephalic tegmentum", EPILEPSY R, 38(1), 2000, pp. 33-44

Abstract

The location and extension of a convulsive area in the brain stem in cats was determined through penicillin microinjections (0.5-1.0 mu l) of a concentrated sodium penicillin solution (500 IU/mu l), stereotactically orientedto multiple structures, in fully awake animals, partially restrained through a rod fixation system that avoided pain, allowed the observation of clinical seizures and simultaneous recording of EEG, EMG and multiple unit activity (MUA) from the injected site and the motor cortex (Cx). Clinical and EEG seizure patterns in relation to the injected sites and penicillin doses were studied in another group of animals using doses from 12.5 IU/0.1 mu l to 125 IU/1.0 mu l. The time relationship between muscular clonus, EEG spikes and MUA at the injected site and Cx were analyzed. The only area in which penicillin induced seizures was the mesencephalic tegmentum (MT). The amount of penicillin but not the stereotactic coordinates determined the seizure type. MT EEC and MUA paroxysms anticipated clinical seizure and Cx EEG spikes. When Cx EEG appeared, they were accompanied by an increase in MUA beginning in the Cx and EMG, followed by significant increase in MT MUA. The sequence of events suggest that MT seizure activity propagates via alternative pathways not involving direct reticulospinal or pyramidal tract pathways. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:05:30