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Titolo:
Reduction of left ventricular mass index with blood pressure reduction in chronic renal failure
Autore:
Tucker, B; Fabbian, F; Giles, M; Johnston, A; Baker, LRI;
Indirizzi:
St Bartholomews Hosp, Dept Nephrol, London EC1A 7BE, England St Bartholomews Hosp London England EC1A 7BE l, London EC1A 7BE, England St Bartholomews Hosp, Dept Cardiol, London EC1A 7BE, England St Bartholomews Hosp London England EC1A 7BE l, London EC1A 7BE, England St Bartholomews Hosp, Dept Clin Pharmacol, London EC1A 7BE, England St Bartholomews Hosp London England EC1A 7BE l, London EC1A 7BE, England Arcispedale St Anna, Dept Nephrol, Ferrara, Italy Arcispedale St Anna Ferrara Italy St Anna, Dept Nephrol, Ferrara, Italy
Titolo Testata:
CLINICAL NEPHROLOGY
fascicolo: 6, volume: 52, anno: 1999,
pagine: 377 - 382
SICI:
0301-0430(199912)52:6<377:ROLVMI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTROPHY; DISEASE; HYPERTENSION; IMPACT; ANEMIA;
Keywords:
ambulatory blood pressure (ABP); anemia; chronic renal failure (CRF); hypertension; left ventricular hypertrophy (LVH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, LRI St Bartholomews Hosp, Dept Nephrol, London EC1A 7BE, England StBartholomews Hosp London England EC1A 7BE C1A 7BE, England
Citazione:
B. Tucker et al., "Reduction of left ventricular mass index with blood pressure reduction in chronic renal failure", CLIN NEPHR, 52(6), 1999, pp. 377-382

Abstract

Aim: We have reported previously in a study of 85 non-diabetic patients with chronic renal failure (CRF) that 24-h ambulatory blood pressure (ABP) recording and echocardiography are required for accurate diagnosis of inadequate blood pressure (BP) control and early left ventricular hypertrophy (LVH). In this study we found that the only independent determinants of left ventricular (LV) mass were hypertension, male sex, body mass index (BMI) and anemia. Little is known about the progression of LVH in patients as they progress from moderate to end-stage renal failure. Patients and methods: We undertook a follow-up observational study in a cohort of 65 (26 male, 12 black Afro-Caribbean and 7 Asian) of those patients originally investigated. Patients who had reached end-stage renal failure (ESRF) were not studied. Results: A statistically significant correlation was found between change in left ventricular mass index (LVMI) and change in mean ABP parameters (r = 0.27 (p < 0.03) for 24-h systolic, r = 0.21 (p < 0.05) for 24-h diastolic. r= 0.29 (p < 0.02) for mean arterial pressure (MAP), r = 0.24 (p < 0.05) for daytime systolic, r = 0.30 (p < 0.02) for nocturnal systolic and r = 0.26(p < 0.05) for nocturnal diastolic BP). Hemoglobin concentration and BMI changed little between the two studies and no other statistically significant correlations were found in respect of any other parameters studied, whichhas allowed us to isolate the effect of one determinant - adequacy of BP control - upon LVH. Conclusion: In patients with moderade chronic renal impairment, reduction in BP is associated with reduction of LVMI over time. Among the antihypertensive agents ACE inhibitors appeared to have the greatestability to reduce LV mass in the subjects with LVH at baseline. Larger interventional studies are needed to determine whether ACE inhibitors are superior to other anti-hypertensive agents in LVH regression in chronic renal failure patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:34:27