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Titolo:
Embryonic stem cell-derived haematopoiesis
Autore:
Hole, N;
Indirizzi:
Univ Durham, Durham DH1 3LE, England Univ Durham Durham England DH1 3LEUniv Durham, Durham DH1 3LE, England
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 3-4, volume: 165, anno: 1999,
pagine: 181 - 189
SICI:
1422-6405(1999)165:3-4<181:ESCH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR GATA-2; VISCERAL YOLK-SAC; IN-VITRO; HEMATOPOIETIC-CELLS; ES CELLS; GENE-EXPRESSION; DEFICIENT MICE; NOD/SCID MICE; MOUSE; DIFFERENTIATION;
Keywords:
differentiation, in vitro; embryonic stem cell; pluripotent cell types; haematopoiesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Hole, N Univ Durham, South Rd, Durham DH1 3LE, England Univ Durham South Rd Durham England DH1 3LE rham DH1 3LE, England
Citazione:
N. Hole, "Embryonic stem cell-derived haematopoiesis", CELLS T ORG, 165(3-4), 1999, pp. 181-189

Abstract

Embryonal stem (ES) cells are pluripotent cell types that in chimaeric mice can give rise to all cellular lineages. Early studies showed that they also had the potential to form mature erythrocytes following in vitro differentiation. In recent years ES cells have been demonstrated to be competent both to produce all haematopoietic lineages following in vitro differentiation and long-term repopulating haematopoietic stem cells. This review discusses the approaches that have been used to produce these haematopoietic cells and the nature of the haematopoietic stem cells that can be isolated. Theutility of the system to both isolate genes involved in control of haematopoiesis and to assess their function following transgenesis is demonstrated. The prospectives for this field a re then discussed in the context of recent developments in human ES cells and evidence of stem cell plasticity. Copyright (C) 1999 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:49:58