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Titolo:
Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages
Autore:
Rosenbauer, F; Waring, JF; Foerster, J; Wietstruk, M; Philipp, D; Horak, I;
Indirizzi:
Free Univ Berlin, Res Inst Mol Pharmacol, Dept Mol Genet, D-12207 Berlin, Germany Free Univ Berlin Berlin Germany D-12207 l Genet, D-12207 Berlin, Germany Free Univ Berlin, Hosp Benjamin Franklin, D-12207 Berlin, Germany Free Univ Berlin Berlin Germany D-12207 ranklin, D-12207 Berlin, Germany
Titolo Testata:
BLOOD
fascicolo: 12, volume: 94, anno: 1999,
pagine: 4274 - 4281
SICI:
0006-4971(199912)94:12<4274:ICSBPA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR FAMILY; TRANSCRIPTION FACTOR; INDUCIBLE GENES; NUCLEAR FACTOR; ELEMENT; GAMMA; RESPONSES; DISTINCT; LEUKEMIA; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Horak, I Free Univ Berlin, Res Inst Mol Pharmacol, Dept Mol Genet, Krahmerstr 6, D-12207 Berlin, Germany Free Univ Berlin Krahmerstr 6 Berlin Germany D-12207 in, Germany
Citazione:
F. Rosenbauer et al., "Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages", BLOOD, 94(12), 1999, pp. 4274-4281

Abstract

Interferon consensus sequence binding protein (ICSBP), a transcription factor of the interferon (IFM) regulatory factor (IRF) family, binds to the IFN-stimulated response element (ISRE) in the regulatory region of IFNs and IFN-stimulated genes (ISG). To identify target genes, which are deregulated by an ICSBP null-mutation in mice (ICSBP-/-), we have analyzed transcription of an ISRE-bearing gene, ISG15. We have found that although ISG15 expression is unchanged in B cells, it is upregulated in macrophages from ICSBP-/-mice. Three factors, ICSBP, IRF-2, and IRF-4/Pip interact with the ISRE inB cells, however only ICSBP and IRF-4/Pip were found to bind this sequencein macrophages of wild-type mice. Although IRF-4 was considered to be a lymphoid-specific factor, we provide evidence for its role in macrophage generegulation. Our results suggest that the formation of cell-type-specific heteromeric complexes between individual IRFs plays a crucial role in regulating IFN responses. (C) 1999 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 14:28:00