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Titolo:
Resistance to trypanosomosis: of markers, genes and mechanisms
Autore:
Teale, A; Agaba, M; Clapcott, S; Gelhaus, A; Haley, C; Hanotte, O; Horstmann, R; Iraqi, F; Kemp, S; Nilsson, P; Schwerin, M; Sekikawa, K; Soller, M; Sugimoto, Y; Womack, J;
Indirizzi:
Int Livestock Res Inst, Nairobi, Kenya Int Livestock Res Inst Nairobi Kenya Livestock Res Inst, Nairobi, Kenya
Titolo Testata:
ARCHIV FUR TIERZUCHT-ARCHIVES OF ANIMAL BREEDING
, volume: 42, anno: 1999,
pagine: 36 - 41
SICI:
0003-9438(1999)42:<36:RTTOMG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BORAN CATTLE; PROTECTIVE ROLE; FACTOR PLAYS; CONGOLENSE; BRUCEI; TRYPANOTOLERANCE; SUSCEPTIBILITY; LEISHMANIASIS; INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Teale, A Univ Stirling, Inst Aquaculture, Stirling FK9 4LA, Scotland Univ Stirling Stirling Scotland FK9 4LA rling FK9 4LA, Scotland
Citazione:
A. Teale et al., "Resistance to trypanosomosis: of markers, genes and mechanisms", ARCH TIER, 42, 1999, pp. 36-41

Abstract

A two species comparative genome scanning approach has ken taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense Using two large murine F-2 and two F-6 advanced intercross populations QTL influencing survival time in mice following challenge with T. congolense were mapped to small confidence intervals on MMU1, 5 and 17. The QTL onMMU17, Tir1, has a sufficiently small confidence interval (<1cM) to justify an immediate search for positional candidate genes at the DNA level. Mapping of trypanotolerance loci in an F-2 cattle resource population is now beginning to reveal bovine resistance QTLs. A key strength of the comparativestrategy derives from overlaying the genetic maps of murine and bovine QTL-containing regions. If, and where, the same genes are used by the two species, this may facilitate localisation of one or more of the genes contributing to variation in resistance to T. congolense trypanosomosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:38:11