Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of ACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction
Autore:
Hugel, S; Horn, M; De Groot, M; Remkes, H; Dienesch, C; Hu, K; Ertl, G; Neubauer, S;
Indirizzi:
Med Univ Klin, D-97080 Wurzburg, Germany Med Univ Klin Wurzburg Germany D-97080 v Klin, D-97080 Wurzburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 277, anno: 1999,
pagine: H2167 - H2175
SICI:
0363-6135(199912)277:6<H2167:EOAIAB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; CONGESTIVE-HEART-FAILURE; CREATINE-KINASE REACTION; EXPERIMENTAL MYOCARDIAL-INFARCTION; DILATED CARDIOMYOPATHY; MAGNETIZATION TRANSFER; VENTRICULAR DILATION; ADRENERGIC-BLOCKADE; SURVIVAL; TERM;
Keywords:
adrenergic antagonist; angiotensin-converting enzyme inhibitors; infarction; remodeling; energy metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hugel, S Med Univ Klin, Josef Schneider Str 2, D-97080 Wurzburg, Germany Med Univ Klin Josef Schneider Str 2 Wurzburg Germany D-97080 any
Citazione:
S. Hugel et al., "Effects of ACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction", AM J P-HEAR, 277(6), 1999, pp. H2167-H2175

Abstract

Chronic treatment with beta-receptor blockers or angiotensin-converting enzyme (ACE) inhibitors in heart failure can reduce mortality and improve left ventricular function, but the mechanisms involved in their beneficial action remain to be fully defined. Our hypothesis was that these agents prevent the derangement of cardiac energy metabolism. Rats were subjected to myocardial infarction (MI) or sham operation. Thereafter, animals were treated with bisoprolol, captopril, or remained untreated. Two months later, cardiac function was measured in the isolated heart by a left ventricular balloon(pressure-volume curves), and energy metabolism of residual intact myocardium was analyzed in terms of total and isoenzyme creatine kinase (CK) activity, steady-state levels (ATP, phosphocreatine), and turnover rates (CK reaction velocity) of high-energy phosphates (P-31 nuclear magnetic resonance)and total creatine content (HPLC). Bisoprolol and partially captopril prevented post-MI hypertrophy and partially prevented left ventricular contractile dysfunction. Residual intact failing myocardium in untreated, infarctedhearts showed a 25% decrease of the total, a 26% decrease of MM-, and a 37% decrease of the mitochondrial CK activity. Total creatine was reduced by 15%, phosphocreatine by 21%, and CK reaction velocity by 41%. Treatment with bisoprolol or captopril largely prevented all of these changes in infarcted hearts. Thus the favorable functional effects of beta-receptor blockers and ACE inhibitors post-MI are accompanied by substantial beneficial effects on cardiac energy metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:17:29